{"id":"W1980917832","doi":"10.1113/jphysiol.2001.013235","title":"Molecular determinants of Au(CN)2− binding and permeability within the cystic fibrosis transmembrane conductance regulator Cl− channel pore","year":2002,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Foundation","keywords":"Cystic fibrosis transmembrane conductance regulator; Chemistry; Selectivity; Biophysics; Mutant; Conductance; Binding site; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001032922,0.0001318594,0.0001891746,0.00007207899,0.00008359244,0.0002129273,0.0001673372,0.0003444957,0.0008209371],"category_scores_gemma":[0.0002782067,0.0001282483,0.0001297898,0.00005256037,0.0002785622,0.0001917075,0.0001575911,0.0002567794,0.0002512737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002638137,"about_ca_system_score_gemma":0.0001034817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009357299,"about_ca_topic_score_gemma":0.0007939743,"domain_scores_codex":[0.9998959,0.00001807447,0.000007534933,0.00001871988,0.0000387687,0.00002096943],"domain_scores_gemma":[0.999856,0.00003714495,0.00004845779,0.000008409706,0.00001641921,0.00003351475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005667302,0.000004894117,0.0002411986,0.000009920567,0.000001549318,0.00003238964,0.00000867514,0.00008233672,0.9992901,0.00004811997,0.00000747647,0.0002166611],"study_design_scores_gemma":[0.00002292282,0.0003714216,0.0335031,0.000005789134,0.00001459004,0.0007568272,0.00006429973,0.005709738,0.9588815,0.0001443008,0.000515479,0.000009997387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986242,0.000148095,0.0008539293,0.00002432505,0.000003476481,0.000008348093,0.0000423562,0.00001525281,0.0002800016],"genre_scores_gemma":[0.9989774,0.00005149616,0.0007282291,0.00001952295,0.000001697636,0.000008124675,0.00004939842,0.000004335657,0.0001597596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009357299,"threshold_uncertainty_score":0.002746284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01955412683490047,"score_gpt":0.2710820605944083,"score_spread":0.2515279337595078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}