{"id":"W1980921374","doi":"10.1371/journal.pone.0039501","title":"Peripheral SLC6A4 DNA Methylation Is Associated with In Vivo Measures of Human Brain Serotonin Synthesis and Childhood Physical Aggression","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":211,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; McGill University","funders":"Canadian Institutes of Health Research; Social Sciences and Humanities Research Council of Canada; Canadian Institute for Advanced Research; GlaxoSmithKline","keywords":"DNA methylation; Methylation; CpG site; Epigenetics; Biology; Molecular biology; Genetics; DNA; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002668401,0.0001131493,0.0001988458,0.00004187001,0.00005397584,0.000008909758,0.00005130986,0.0001106719,0.00001375847],"category_scores_gemma":[0.0002115327,0.00009853907,0.00003017081,0.000081282,0.00004402018,0.000008094318,0.00003308061,0.00006439634,3.395427e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001450099,"about_ca_system_score_gemma":0.00001548029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001607403,"about_ca_topic_score_gemma":0.00003906873,"domain_scores_codex":[0.9991738,0.0001306121,0.0001471941,0.0001753488,0.0002068089,0.0001662802],"domain_scores_gemma":[0.9995735,0.00003746881,0.000125746,0.0001431429,0.00006360907,0.00005647732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000270881,0.0008405782,0.07544264,0.00001626788,0.0000975873,1.652588e-7,0.0006065986,0.000003460357,0.9217238,0.000008413494,0.000006200577,0.001227154],"study_design_scores_gemma":[0.000343679,0.0002156423,0.1337294,0.00017544,0.0000483586,1.312696e-7,0.00002900598,0.00007509445,0.8652053,0.00005495908,0.00001212229,0.0001107788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982236,0.001245278,0.00003176487,0.00008389282,0.000005852499,0.0001879037,0.00001561483,0.000006074943,0.0002000119],"genre_scores_gemma":[0.9993977,0.00009934685,0.0002663423,0.00002816068,0.00008113815,0.00002814253,0.0000250693,0.00001904264,0.00005505431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05828678,"threshold_uncertainty_score":0.4018306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02920350537256293,"score_gpt":0.2522893944339208,"score_spread":0.2230858890613578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}