{"id":"W1980922145","doi":"10.1371/journal.pone.0015887","title":"Mouse Survival Motor Neuron Alleles That Mimic SMN2 Splicing and Are Inducible Rescue Embryonic Lethality Early in Development but Not Late","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Aging; National Institutes of Health; Canadian Institutes of Health Research; National Institute of Neurological Disorders and Stroke; University of Ottawa; Families of Spinal Muscular Atrophy","keywords":"Biology; Spinal muscular atrophy; SMN1; Allele; Gene targeting; Cre recombinase; Motor neuron; Embryonic stem cell; Genetics; Cell biology; Transgene; Gene; Genetically modified mouse; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002488531,0.0008095059,0.0002679032,0.0005210139,0.0001927642,0.0002039768,0.0004633697,0.0006100443,0.002604405],"category_scores_gemma":[0.0001083102,0.000323737,0.000326984,0.0001483927,0.000347181,0.0001811726,0.000343641,0.0008213581,0.001194472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002736439,"about_ca_system_score_gemma":0.0002128106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001719317,"about_ca_topic_score_gemma":0.000811141,"domain_scores_codex":[0.9996748,0.00005418854,0.00004366555,0.00006972042,0.000118022,0.00003974065],"domain_scores_gemma":[0.9997408,0.00002681755,0.0001208153,0.00003195046,0.00001520674,0.00006431565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004472633,0.00002826256,0.0001154977,0.00002125713,0.000003846889,0.00007625297,0.0000124245,0.00003805037,0.9982522,0.0001543979,0.00005230334,0.001200808],"study_design_scores_gemma":[0.00007053404,0.0004813714,0.003792547,0.00001975613,0.00002367356,0.00171972,0.00002827839,0.0008935005,0.9816892,0.00009826612,0.0111732,0.000009901365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9610001,0.0006621137,0.03166937,0.0002147126,0.000115247,0.000258069,0.001548129,0.0006448253,0.003887423],"genre_scores_gemma":[0.922534,0.001076519,0.04257114,0.0002047973,0.00002916937,0.0006090709,0.004282442,0.0003158815,0.02837696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002604405,"threshold_uncertainty_score":0.00871259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08899886930979474,"score_gpt":0.2751644004162979,"score_spread":0.1861655311065032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}