{"id":"W1980930214","doi":"10.1038/cdd.2015.16","title":"Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation","year":2015,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":308,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institute on Aging; Alzheimer Society; Canadian Institutes of Health Research; National Institutes of Health; Journal of Gastroenterology and Hepatology Foundation; McGill University","keywords":"Inflammasome; NLRP1; Caspase 1; Cell biology; Chemistry; AIM2; Small interfering RNA; Caspase 8; Biology; Caspase; Programmed cell death; Receptor; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004064183,0.0004986495,0.0007264339,0.0006901848,0.0003427715,0.001115839,0.0003167653,0.0004521766,0.001410926],"category_scores_gemma":[0.0003707749,0.0002459851,0.0006042151,0.0003729456,0.0005040707,0.0008862385,0.0005238391,0.001215033,0.0006948645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009090759,"about_ca_system_score_gemma":0.0004601495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003439781,"about_ca_topic_score_gemma":0.0007511342,"domain_scores_codex":[0.9993394,0.00009009631,0.00007616737,0.0001509929,0.0001535688,0.0001898113],"domain_scores_gemma":[0.9996139,0.00002129048,0.0001688106,0.00003404584,0.00007773886,0.00008417704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001415837,0.00008360158,0.00126396,0.0001548176,0.00002441084,0.0004510182,0.0001012896,0.0001035449,0.9911513,0.0006146785,0.0002233574,0.00441211],"study_design_scores_gemma":[0.0001219186,0.0006070238,0.05685807,0.00006914078,0.00009984407,0.003186675,0.0005085823,0.001252391,0.9310213,0.001563781,0.004679685,0.00003140945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9689974,0.01676285,0.008581176,0.0006264564,0.000170527,0.00006268726,0.0008319422,0.0002264981,0.003740612],"genre_scores_gemma":[0.9903998,0.002765676,0.003235881,0.0001139932,0.00003252265,0.00007140754,0.0005037918,0.00002755646,0.002849375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001410926,"threshold_uncertainty_score":0.00659585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01302704419483811,"score_gpt":0.2089083747576606,"score_spread":0.1958813305628225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}