{"id":"W1980930214","doi":"10.1038/cdd.2015.16","title":"Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation","year":2015,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":308,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institute on Aging; Alzheimer Society; Canadian Institutes of Health Research; National Institutes of Health; Journal of Gastroenterology and Hepatology Foundation; McGill University","keywords":"Inflammasome; NLRP1; Caspase 1; Cell biology; Chemistry; AIM2; Small interfering RNA; Caspase 8; Biology; Caspase; Programmed cell death; Receptor; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001837594,0.0001954122,0.0001653606,0.0001194277,0.0001155921,0.00004654129,0.00005910308,0.0001813971,0.000006269021],"category_scores_gemma":[0.0001823368,0.000196931,0.00004406803,0.00008953096,0.00006181336,0.00006435262,0.00006236812,0.00009256693,0.000001277947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003405959,"about_ca_system_score_gemma":0.00008437118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003504518,"about_ca_topic_score_gemma":0.00003500702,"domain_scores_codex":[0.9988861,0.0001023769,0.0003245011,0.0003310434,0.0001781474,0.0001778433],"domain_scores_gemma":[0.999162,0.00001591731,0.0002832534,0.0001686649,0.0002886539,0.00008152219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002434419,0.00008607255,0.03812055,0.00005514886,0.00005003959,3.140611e-7,0.0002963426,0.0002046044,0.9593931,0.0001466433,0.0003462873,0.001057453],"study_design_scores_gemma":[0.0009058533,0.0002334845,0.1514315,0.00003004476,0.00004129486,0.000002898001,0.0001563561,0.0006898985,0.8459843,0.0001503244,0.0001853049,0.0001887503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985703,0.000184841,0.0004781881,0.0001038737,0.0001715523,0.0002828841,0.000007764731,0.00001847673,0.0001820971],"genre_scores_gemma":[0.9982248,0.0001027286,0.00005894333,0.00003515377,0.0001305099,0.0000258944,0.001037516,0.00002091644,0.0003635703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1134088,"threshold_uncertainty_score":0.8030611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01302704419483811,"score_gpt":0.2089083747576606,"score_spread":0.1958813305628225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}