{"id":"W1980949293","doi":"10.1038/nature04780","title":"Thermodynamic control of asymmetric amplification in amino acid catalysis","year":2006,"lang":"en","type":"article","venue":"Nature","topic":"Origins and Evolution of Life","field":"Physics and Astronomy","cited_by":396,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Engineering and Physical Sciences Research Council; AstraZeneca","keywords":"Autocatalysis; Homochirality; Chemistry; Enantiomer; Enantiomeric excess; Chirality (physics); Enantioselective synthesis; Catalysis; Yield (engineering); Molecule; Autocatalytic reaction; Combinatorial chemistry; Stereochemistry; Organic chemistry; Thermodynamics; Physics; Chiral symmetry breaking","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008573752,0.0003776289,0.0005659245,0.0005917106,0.001085652,0.001704872,0.001169875,0.0006710271,0.006344188],"category_scores_gemma":[0.003336565,0.0004421253,0.000238139,0.0003271349,0.001894784,0.002438951,0.001151005,0.001054569,0.0007917975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001044504,"about_ca_system_score_gemma":0.0005703239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006396062,"about_ca_topic_score_gemma":0.0008256599,"domain_scores_codex":[0.9996029,0.00007239174,0.00001891599,0.0000743108,0.000135895,0.00009569882],"domain_scores_gemma":[0.9990688,0.0005721288,0.00008370729,0.00007799044,0.0001070976,0.00009034556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004628878,0.000276365,0.00192523,0.0003111525,0.00004660725,0.0004960438,0.0003799353,0.04072339,0.2740107,0.6495874,0.00200801,0.02977224],"study_design_scores_gemma":[0.0001178684,0.0002410008,0.002102693,0.00002329027,0.00002409127,0.0003655888,0.0002703971,0.4001706,0.1477286,0.443909,0.004914332,0.0001324688],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8772416,0.003382406,0.06681911,0.003308096,0.0006663627,0.00004583969,0.0001138205,0.0003931377,0.04802961],"genre_scores_gemma":[0.996759,0.0004143916,0.001164788,0.00006169333,0.00009021426,0.00001203435,0.00001850233,0.00002979087,0.001449656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006344188,"threshold_uncertainty_score":0.02122349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00297756151075011,"score_gpt":0.2214816637732417,"score_spread":0.2185041022624916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}