{"id":"W1980955186","doi":"10.1097/qad.0b013e3283350f08","title":"Pharmacokinetics of double-dose raltegravir in two patients with HIV infection and tuberculosis","year":2009,"lang":"en","type":"letter","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Raltegravir; Efavirenz; Integrase inhibitor; Medicine; Rifabutin; Pharmacology; Tuberculosis; Pharmacokinetics; Integrase; Reverse-transcriptase inhibitor; Drug; Virology; Viral load; Internal medicine; Human immunodeficiency virus (HIV); Antiretroviral therapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006550718,0.0002858629,0.0004851381,0.0003754959,0.00002109479,0.00001019431,0.00003803068,0.0001599505,0.00006065644],"category_scores_gemma":[0.00000491191,0.0002078521,0.00005677238,0.0002743353,0.00005008673,0.00005514288,0.0000220772,0.0005079489,0.00001564343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001063407,"about_ca_system_score_gemma":0.00005853105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001064757,"about_ca_topic_score_gemma":0.00001194423,"domain_scores_codex":[0.9988177,0.00003511404,0.0002980652,0.0002910788,0.0003296476,0.0002283496],"domain_scores_gemma":[0.9995232,0.00003176858,0.0001132379,0.000187335,0.00008957964,0.00005493597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002861934,0.0002979031,0.8609387,0.0001984654,0.0002563556,0.0001274227,0.0001843823,0.000002393732,0.0000150403,0.000004134734,0.1270707,0.01061836],"study_design_scores_gemma":[0.04324734,0.001167217,0.5769205,0.001285821,0.001727142,0.00003069745,0.000008829302,0.00002529589,0.001836338,0.00005580783,0.3730298,0.0006651565],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9395949,0.0001645724,0.000007684255,0.05681767,0.00009216866,0.0008971377,0.00002193004,0.00003601257,0.00236793],"genre_scores_gemma":[0.8855283,0.0008715633,0.003271009,0.08773615,0.0009024763,0.0001380656,0.003640012,0.0001429703,0.01776941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2840182,"threshold_uncertainty_score":0.8475963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015805297462988,"score_gpt":0.2718317195774141,"score_spread":0.2616736666027842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}