{"id":"W1980972723","doi":"10.1038/ijo.2014.35","title":"Inhibition of stearoyl-CoA desaturase-1 in differentiating 3T3-L1 preadipocytes upregulates elongase 6 and downregulates genes affecting triacylglycerol synthesis","year":2014,"lang":"en","type":"article","venue":"International Journal of Obesity","topic":"Fatty Acid Research and Health","field":"Nursing","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Agilent Technologies","keywords":"Stearoyl-CoA Desaturase; Adipogenesis; Chemistry; Adipose tissue; 3T3-L1; Internal medicine; Fatty acid; Endocrinology; Adipocyte; Gene expression; Fatty acid synthesis; Lipogenesis; Downregulation and upregulation; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002235376,0.0005212014,0.0006263219,0.0004796939,0.0003488383,0.0006349628,0.0002967861,0.0004210189,0.003681418],"category_scores_gemma":[0.0001541191,0.0003530687,0.0006543414,0.0004078012,0.0005034263,0.0002487497,0.0002738909,0.001964108,0.0008989606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006672105,"about_ca_system_score_gemma":0.0006034491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002777065,"about_ca_topic_score_gemma":0.005655251,"domain_scores_codex":[0.999696,0.00002826643,0.00003793317,0.00006305748,0.00006905829,0.0001057682],"domain_scores_gemma":[0.999754,0.00006982283,0.00003812164,0.00002881268,0.00002445844,0.00008478394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008061534,0.00009878031,0.0001774207,0.00003824513,0.000009192891,0.00006584889,0.00002968679,0.00005682417,0.997813,0.0001206348,0.0001027266,0.0006814848],"study_design_scores_gemma":[0.00006714843,0.0004591475,0.003172397,0.000005803229,0.00002574808,0.00007411766,0.00008751277,0.0004342087,0.993619,0.00004813316,0.002000817,0.000006049102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876622,0.003161414,0.002022449,0.0007290909,0.0004446877,0.0000644786,0.002492188,0.0001999744,0.003223446],"genre_scores_gemma":[0.9826414,0.002090979,0.002697351,0.0003858866,0.00006743747,0.00009278862,0.002405945,0.00007430081,0.009543853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003681418,"threshold_uncertainty_score":0.01231557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01379488679360477,"score_gpt":0.2844310725405311,"score_spread":0.2706361857469264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}