{"id":"W1981020155","doi":"10.1371/journal.pgen.1002718","title":"Meta-Analysis of Genome-Wide Scans for Total Body BMD in Children and Adults Reveals Allelic Heterogeneity and Age-Specific Effects at the WNT16 Locus","year":2012,"lang":"en","type":"review","venue":"PLoS Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":168,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Erasmus+; Education, Audiovisual and Culture Executive Agency; Medical Research Council; Novo Nordisk Fonden; Vetenskapsrådet; Novo Nordisk; University of Bristol; Erasmus Medisch Centrum; ZonMw; Stiftelsen för Strategisk Forskning; Erasmus Universiteit Rotterdam; Göteborgs Universitet; European Commission; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust","keywords":"Biology; Locus (genetics); Minor allele frequency; Genome-wide association study; Linkage disequilibrium; Bone mineral; Genetics; Quantitative trait locus; Single-nucleotide polymorphism; Genotyping; Allele; Population; Bone density; Endocrinology; Internal medicine; Allele frequency; Genotype; Gene; Medicine; Osteoporosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01227913,0.002036929,0.005817171,0.002920584,0.0007534476,0.003117307,0.001924271,0.001760125,0.002335656],"category_scores_gemma":[0.0182696,0.001052984,0.01562354,0.004830829,0.0008334403,0.00101562,0.001708676,0.001941483,0.0003039101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007114873,"about_ca_system_score_gemma":0.0006871105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005272748,"about_ca_topic_score_gemma":0.01040505,"domain_scores_codex":[0.9906988,0.004031642,0.001392036,0.002565537,0.0008925343,0.0004195496],"domain_scores_gemma":[0.9833558,0.01102133,0.001910448,0.002881827,0.0004839728,0.0003465937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.004372845,0.00002591665,0.3493725,0.00284579,0.6232362,0.0007641804,0.0001516352,0.001216962,0.003231528,0.0003673469,0.001049646,0.01336531],"study_design_scores_gemma":[0.0007894699,0.0005462098,0.4612223,0.0006218409,0.527451,0.001339677,0.0001994709,0.002294123,0.001054823,0.0013297,0.003098965,0.00005238375],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.618634,0.3582294,0.01235043,0.002064214,0.0005772038,0.0001026185,0.00571489,0.0007162198,0.001610938],"genre_scores_gemma":[0.9776334,0.01551893,0.003705737,0.000602452,0.0001942288,0.00008160318,0.001722015,0.0001393082,0.0004023542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01227913,"threshold_uncertainty_score":0.06493896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06179806460265336,"score_gpt":0.3027088785434597,"score_spread":0.2409108139408063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}