{"id":"W1981040687","doi":"10.1523/jneurosci.5115-09.2010","title":"Suppression of the Intrinsic Apoptosis Pathway by Synaptic Activity","year":2010,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Scotland; Directorate for Biological Sciences; Wellcome Trust; Canadian Institutes of Health Research; Tenovus; European Molecular Biology Organization","keywords":"Puma; Downregulation and upregulation; Apoptosome; Cell biology; Apoptosis; Premovement neuronal activity; Cytochrome c; Biology; Caspase-9; Caspase; Chemistry; Neuroscience; Programmed cell death; Mitochondrion; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001735103,0.00004971186,0.00006814542,0.00001970916,0.00006094715,0.00001126203,0.0002408738,0.00005391371,0.00000310605],"category_scores_gemma":[0.0001471568,0.00002891322,0.00007205885,0.00008267269,0.00009600636,0.000007714508,0.00007690944,0.0001314523,1.41091e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002482663,"about_ca_system_score_gemma":0.00005059398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001565451,"about_ca_topic_score_gemma":0.000001102516,"domain_scores_codex":[0.9994891,0.00003410255,0.0001275893,0.00009173841,0.0001787842,0.00007874504],"domain_scores_gemma":[0.9994795,0.000008119807,0.0002405545,0.0001663472,0.00006544733,0.00004004261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001637632,0.00004357376,0.0002114478,0.000002949194,0.000001195798,2.903281e-7,0.000006323336,0.00001747131,0.9949964,0.00002076818,0.0002196671,0.004463525],"study_design_scores_gemma":[0.0001087839,0.0001825397,0.01367316,0.000006726458,0.000004732367,0.00004085665,0.000002913986,0.0001022389,0.9804246,0.00003706858,0.005383491,0.00003293222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976382,0.00002881143,0.0009815632,0.000190752,0.001078482,0.00003946185,0.000002657563,7.922211e-7,0.00003923335],"genre_scores_gemma":[0.9995831,0.00005004225,0.0001092751,0.00006719388,0.00006457671,3.225038e-7,1.891351e-7,0.000003598941,0.0001217063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01457185,"threshold_uncertainty_score":0.1179047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007518191738063815,"score_gpt":0.2275694105697817,"score_spread":0.2200512188317179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}