{"id":"W1981054886","doi":"10.1038/ng.2218","title":"KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron","year":2012,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":337,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Agence Nationale de la Recherche","keywords":"Nephron; Biology; Distal convoluted tubule; Hyperkalemia; Mutation; Genetics; Endocrinology; Internal medicine; Kidney; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001993017,0.001009348,0.0003518892,0.0004904243,0.0003889634,0.0004360483,0.0003983277,0.001165483,0.001723583],"category_scores_gemma":[0.0006018735,0.0002528739,0.0004087012,0.0004098837,0.0007314399,0.0002650925,0.0004670679,0.0006987669,0.0003142183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004915763,"about_ca_system_score_gemma":0.0003367986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002370129,"about_ca_topic_score_gemma":0.00284352,"domain_scores_codex":[0.9997088,0.00004342393,0.00004110268,0.00005462436,0.0001077377,0.00004426249],"domain_scores_gemma":[0.9994814,0.0001685326,0.0001478135,0.00002493054,0.00003912883,0.0001382683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001728427,0.0001355523,0.02952015,0.0002016283,0.0003037438,0.08194969,0.0005136427,0.001724942,0.8700772,0.002068241,0.001616444,0.01016047],"study_design_scores_gemma":[0.0009877529,0.0006365211,0.2992125,0.0001240618,0.0009451091,0.2655005,0.0007398966,0.01589146,0.3992968,0.006332024,0.01011259,0.0002208631],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950467,0.0004463793,0.00233535,0.0004455404,0.00006240325,0.000011973,0.0002688445,0.000170436,0.001212455],"genre_scores_gemma":[0.9987037,0.00007661935,0.0005917543,0.00008757483,0.00002259884,0.000003363778,0.00006465442,0.00002745023,0.0004221421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002370129,"threshold_uncertainty_score":0.005765975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008375350318252697,"score_gpt":0.2348046577442116,"score_spread":0.2264293074259588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}