{"id":"W1981087418","doi":"10.1016/j.bbrc.2013.07.044","title":"Natural CD8+25+ regulatory T cell-secreted exosomes capable of suppressing cytotoxic T lymphocyte-mediated immunity against B16 melanoma","year":2013,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Saskatchewan Cancer Agency","funders":"Health Canada; Canadian Cancer Society; Saskatchewan Cancer Agency; Canadian Institutes of Health Research; Saskatchewan Health Research Foundation; Breast Cancer Research Foundation","keywords":"Cytotoxic T cell; Microvesicles; CD8; Immunology; Melanoma; Immunity; Biology; T lymphocyte; Cancer research; Cell biology; Chemistry; Immune system; Gene; microRNA; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003735046,0.0002221337,0.000259655,0.0001010557,0.0003641562,0.00007443879,0.001289589,0.0002528849,0.00002797568],"category_scores_gemma":[0.000658298,0.0001982672,0.0001468435,0.000386344,0.001959868,0.0000247959,0.001407279,0.0005072019,0.00003848458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005957996,"about_ca_system_score_gemma":0.0002314231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001385262,"about_ca_topic_score_gemma":0.000004519533,"domain_scores_codex":[0.9977316,0.0005029744,0.0003860781,0.0004199132,0.0004445295,0.0005148923],"domain_scores_gemma":[0.9967002,0.0003432824,0.0001135739,0.001981341,0.0005142225,0.0003474399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005620369,0.0004332413,0.0002445224,0.00007654221,0.00004178664,9.795772e-7,0.00004132829,4.21415e-7,0.9962388,0.0001661479,0.001693453,0.001006555],"study_design_scores_gemma":[0.0006427604,0.0001245281,0.00339764,0.00005783901,0.00001523963,0.0000024689,0.0001898885,0.001295037,0.9919756,0.0003153284,0.001737682,0.000245969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886864,0.008962668,0.00001193126,0.0003995938,0.00002390646,0.0003300368,0.00007001756,0.00002677326,0.00148872],"genre_scores_gemma":[0.9956957,0.001482053,0.001202552,0.00006814162,0.00008317175,0.0001135137,0.00087586,0.0000315758,0.0004475109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007480615,"threshold_uncertainty_score":0.80851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02403919950354895,"score_gpt":0.2989378392613334,"score_spread":0.2748986397577845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}