{"id":"W1981087418","doi":"10.1016/j.bbrc.2013.07.044","title":"Natural CD8+25+ regulatory T cell-secreted exosomes capable of suppressing cytotoxic T lymphocyte-mediated immunity against B16 melanoma","year":2013,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Saskatchewan Cancer Agency","funders":"Health Canada; Canadian Cancer Society; Saskatchewan Cancer Agency; Canadian Institutes of Health Research; Saskatchewan Health Research Foundation; Breast Cancer Research Foundation","keywords":"Cytotoxic T cell; Microvesicles; CD8; Immunology; Melanoma; Immunity; Biology; T lymphocyte; Cancer research; Cell biology; Chemistry; Immune system; Gene; microRNA; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001938236,0.0002399512,0.0001963421,0.0001264178,0.0001642664,0.0003700366,0.0001812746,0.0002678467,0.001008221],"category_scores_gemma":[0.0002078322,0.0001287445,0.0001860194,0.00007352372,0.0002152866,0.0002441616,0.0001790723,0.0006960565,0.000246605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001578207,"about_ca_system_score_gemma":0.0002519772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001334867,"about_ca_topic_score_gemma":0.0002749531,"domain_scores_codex":[0.9998755,0.00002803138,0.00001085526,0.00001551995,0.00002643258,0.00004354921],"domain_scores_gemma":[0.9999237,0.00002231097,0.000009538411,0.00001386208,0.000007037659,0.0000235195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007660103,0.0002227041,0.0002835912,0.00005625882,0.00001088699,0.0001446145,0.00002526656,0.000372775,0.9928414,0.0003344969,0.0002213775,0.004720612],"study_design_scores_gemma":[0.0003120402,0.002213982,0.002989132,0.00001106391,0.00004587388,0.0004772801,0.00004501801,0.001873333,0.9870401,0.0001931933,0.004789705,0.000009249378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966793,0.000631829,0.001202825,0.00009191878,0.00007960091,0.0000428901,0.00008517141,0.00004306241,0.001143441],"genre_scores_gemma":[0.9970276,0.0003058038,0.001011486,0.00005816263,0.0000256136,0.00003652862,0.0001873163,0.000009574104,0.001337903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001008221,"threshold_uncertainty_score":0.003372788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02403919950354895,"score_gpt":0.2989378392613334,"score_spread":0.2748986397577845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}