{"id":"W1981159996","doi":"10.1097/00001756-200105080-00037","title":"Nitrotyrosination contributes minimally to toxicity of mutant SOD1 associated with ALS","year":2001,"lang":"de","type":"article","venue":"Neuroreport","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"SOD1; Amyotrophic lateral sclerosis; Mutant; Motor neuron; Nitric oxide; Spinal cord; Nitrotyrosine; Glutamate receptor; Cell biology; Nitric oxide synthase; Neuroscience; Biology; Chemistry; Biochemistry; Medicine; Internal medicine; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002011067,0.0003287011,0.0003401844,0.000174903,0.0001686166,0.0003265192,0.0002055136,0.0003742941,0.0006555101],"category_scores_gemma":[0.0003241591,0.0001872298,0.0002367197,0.0001043387,0.0002765209,0.0002269228,0.0002378969,0.0004689863,0.0002376699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002671268,"about_ca_system_score_gemma":0.0002013389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007231223,"about_ca_topic_score_gemma":0.0008539562,"domain_scores_codex":[0.9998376,0.00002485822,0.00001767894,0.00003276351,0.00004816939,0.00003896876],"domain_scores_gemma":[0.9997017,0.00004400967,0.00007477363,0.00004725887,0.00004518435,0.00008714547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001055624,0.00002037378,0.0007861392,0.00002195328,0.000006270915,0.0001461154,0.00001411345,0.00005727231,0.9981833,0.00004138867,0.00001439586,0.0006031236],"study_design_scores_gemma":[0.00002817018,0.000642693,0.03279429,0.00001226955,0.00005983971,0.00326383,0.0000620206,0.001619593,0.9597332,0.0001577072,0.001618954,0.000007433793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985225,0.000575236,0.0004536113,0.00002196343,0.000005181518,0.000005125676,0.00004881483,0.00001910925,0.0003484432],"genre_scores_gemma":[0.9984474,0.0003877386,0.0003126577,0.00001427061,0.000005110053,0.000006123917,0.0001697328,0.00001029418,0.000646789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007231223,"threshold_uncertainty_score":0.002192855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03095432691486555,"score_gpt":0.2974899952966035,"score_spread":0.266535668381738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}