{"id":"W1981183371","doi":"10.1371/journal.pone.0073138","title":"Development and Validation of Non-Integrative, Self-Limited, and Replicating Minicircles for Safe Reporter Gene Imaging of Cell-Based Therapies","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Minicircle; Bioluminescence imaging; Luciferase; Biology; Reporter gene; Cell biology; Plasmid; Computational biology; Transfection; Gene; Bioinformatics; Genetics; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002223371,0.000652862,0.0004676364,0.0004592431,0.0002656844,0.0007169276,0.0008546286,0.0007738154,0.0005768374],"category_scores_gemma":[0.002494777,0.0003105883,0.0005463025,0.0002495338,0.0005313628,0.0005894925,0.0003276815,0.0008845676,0.0005738756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005432635,"about_ca_system_score_gemma":0.000673538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005861366,"about_ca_topic_score_gemma":0.0006843056,"domain_scores_codex":[0.9986814,0.0003174063,0.0001191489,0.0002127992,0.0005720291,0.00009722514],"domain_scores_gemma":[0.9980267,0.0005434506,0.0004208702,0.0002873013,0.0005176436,0.0002040888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003131195,0.00004525817,0.0001297068,0.00005590669,0.000003969888,0.00003010819,0.00003271384,0.0002867399,0.9968321,0.0001342493,0.00003325754,0.002384784],"study_design_scores_gemma":[0.00001148625,0.0006964319,0.0007906263,0.000009665294,0.00001149471,0.0001414532,0.00001604101,0.001289633,0.9952519,0.00002772098,0.001745842,0.00000771842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8175089,0.004037534,0.1738802,0.0003139615,0.0001154457,0.001535623,0.0006677188,0.0006035193,0.001337074],"genre_scores_gemma":[0.769984,0.003464191,0.2183567,0.0001616524,0.00004583835,0.00100588,0.002936506,0.0002686594,0.003776566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002223371,"threshold_uncertainty_score":0.01175845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02760405863864547,"score_gpt":0.2705397236949564,"score_spread":0.242935665056311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}