{"id":"W1981187216","doi":"10.1016/j.jmb.2004.03.011","title":"Location of Divergent Region 2 on the Three-dimensional Structure of Cardiac Muscle Ryanodine Receptor/Calcium Release Channel","year":2004,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Center for Research Resources; Canadian Institutes of Health Research; National Institutes of Health; Muscular Dystrophy Association; American Heart Association","keywords":"Ryanodine receptor; Green fluorescent protein; Ryanodine receptor 2; Gene isoform; Complementary DNA; Biology; Calcium; Calcium in biology; Cell biology; Biochemistry; Cytoplasm; Biophysics; Endoplasmic reticulum; Molecular biology; Chemistry; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001869726,0.0001211098,0.0002062853,0.00008768079,0.00004366169,0.000002602009,0.000139995,0.0001969301,0.00001561588],"category_scores_gemma":[0.0001902882,0.00008207926,0.0001792384,0.0001526695,0.0001184262,0.000003815904,0.00004619694,0.0001238858,0.000001387127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002703312,"about_ca_system_score_gemma":0.0001171217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001421623,"about_ca_topic_score_gemma":0.000002577191,"domain_scores_codex":[0.9990641,0.0001229795,0.0003763094,0.0001476864,0.0001701624,0.000118765],"domain_scores_gemma":[0.9986041,0.00001559724,0.0005030461,0.0002153492,0.0006082256,0.00005370142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003402946,0.00007456513,0.0001224261,0.0000152686,0.00009765531,0.000001300092,0.00002569006,0.013945,0.9830608,0.001032022,0.0005142344,0.0007706974],"study_design_scores_gemma":[0.0006378957,0.001223859,0.001760322,0.00007134728,0.00003651599,0.00002313637,0.00003897569,0.00006862514,0.9928314,0.001557932,0.001653122,0.00009683555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783059,0.001355518,0.01796439,0.001325322,0.0008857526,0.0001272663,0.00001215586,0.000002076638,0.0000216611],"genre_scores_gemma":[0.9990532,0.00009860513,0.0002365528,0.0002302941,0.0003051965,0.000001284364,0.00004593029,0.00001164037,0.00001728342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02074736,"threshold_uncertainty_score":0.3347095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01431182651542899,"score_gpt":0.2416283546938505,"score_spread":0.2273165281784216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}