{"id":"W1981202500","doi":"10.1016/j.celrep.2013.07.003","title":"Common Fragile Site Profiling in Epithelial and Erythroid Cells Reveals that Most Recurrent Cancer Deletions Lie in Fragile Sites Hosting Large Genes","year":2013,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer; Association pour la Recherche sur le Cancer","keywords":"Chromosomal fragile site; Biology; Gene; Genetics; Suppressor; Genome; Cancer; Chromosome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001762968,0.0001905187,0.0001936655,0.00007106359,0.00008621553,0.00004043032,0.00006866248,0.0001275402,0.00005126462],"category_scores_gemma":[0.00002806156,0.0001943653,0.0000382928,0.0001196216,0.00003934772,0.000008296607,0.0001798861,0.000135874,0.00000598572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002071968,"about_ca_system_score_gemma":0.00005868211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002952622,"about_ca_topic_score_gemma":0.0008076658,"domain_scores_codex":[0.9986003,0.00004837944,0.0003838205,0.0004901356,0.0001187521,0.0003585936],"domain_scores_gemma":[0.9994423,0.00001581747,0.0001681856,0.000240453,0.00004804455,0.00008514932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004701021,0.00007484914,0.2888643,0.00003687684,0.00000349031,0.00002513826,0.0001048445,0.00009977409,0.7093312,3.585093e-7,0.0004308856,0.001023638],"study_design_scores_gemma":[0.0003434633,0.00006513971,0.1416284,0.00006202987,0.000007279777,0.00001744242,0.0001672306,0.0001673694,0.8523651,0.00009351667,0.004783629,0.0002993818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934656,0.005272411,0.00002199035,0.00006841299,0.000200897,0.000489482,0.00003265826,0.000008668332,0.0004398937],"genre_scores_gemma":[0.9954935,0.003013704,0.0006401626,0.0002028845,0.00002985898,0.0001265058,0.0001994874,0.00002920461,0.0002646518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1472359,"threshold_uncertainty_score":0.7925987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01089984624065356,"score_gpt":0.2380929070224521,"score_spread":0.2271930607817986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}