{"id":"W1981218311","doi":"10.1101/gad.2004811","title":"Regulation of alternative splicing by the core spliceosomal machinery","year":2011,"lang":"en","type":"article","venue":"Genes & Development","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Ontario Genomics; National Cancer Institute; Ontario Genomics Institute; Genome Canada","keywords":"Biology; Exon; snRNP; RNA splicing; Alternative splicing; Small nuclear ribonucleoprotein; Genetics; Ribonucleoprotein; Mature messenger RNA; Spliceosome; Post-transcriptional modification; RNA; RNA-binding protein; Exonic splicing enhancer; Intron; Nonsense-mediated decay; Gene; Exon skipping; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002151895,0.0001902855,0.0002004274,0.0002025838,0.0001528049,0.0005854163,0.000154996,0.0001643667,0.0006024925],"category_scores_gemma":[0.0001756775,0.0001165091,0.0001686071,0.0001181502,0.0002310632,0.0002818693,0.0003235765,0.0002480004,0.0004974342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002631104,"about_ca_system_score_gemma":0.0001409393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000202589,"about_ca_topic_score_gemma":0.0002688348,"domain_scores_codex":[0.9998216,0.00003256732,0.00001611815,0.0000496914,0.00005601861,0.00002410942],"domain_scores_gemma":[0.9998534,0.00002649423,0.00003715598,0.00002393342,0.0000315024,0.00002752989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003287091,0.00000595659,0.0007755297,0.00002315737,0.000004174025,0.00006341002,0.00001617792,0.00006550072,0.9935808,0.000806656,0.00003619896,0.004589549],"study_design_scores_gemma":[0.00001112452,0.0001439683,0.02005145,0.00001375848,0.0000196369,0.0008223117,0.0000671773,0.003755483,0.9663354,0.00198939,0.006781488,0.000008741838],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719278,0.006519563,0.01561207,0.0001886976,0.00004419342,0.00001594434,0.0002009022,0.0001882166,0.00530273],"genre_scores_gemma":[0.9931743,0.001462764,0.00355457,0.00004303941,0.00001573499,0.000008791758,0.0002569728,0.0000194906,0.001464418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006024925,"threshold_uncertainty_score":0.002015531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0292477176101967,"score_gpt":0.2647319895886235,"score_spread":0.2354842719784268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}