{"id":"W1981218311","doi":"10.1101/gad.2004811","title":"Regulation of alternative splicing by the core spliceosomal machinery","year":2011,"lang":"en","type":"article","venue":"Genes & Development","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Ontario Genomics; National Cancer Institute; Ontario Genomics Institute; Genome Canada","keywords":"Biology; Exon; snRNP; RNA splicing; Alternative splicing; Small nuclear ribonucleoprotein; Genetics; Ribonucleoprotein; Mature messenger RNA; Spliceosome; Post-transcriptional modification; RNA; RNA-binding protein; Exonic splicing enhancer; Intron; Nonsense-mediated decay; Gene; Exon skipping; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002004111,0.00009728219,0.00008346924,0.00002509661,0.00009280609,0.000006593544,0.0002023611,0.00004626358,0.0000343744],"category_scores_gemma":[0.00001568452,0.00006866852,0.00003431787,0.00005721803,0.00005060814,0.000002868117,0.0001290101,0.00004685268,0.000008075389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001424776,"about_ca_system_score_gemma":0.00007201244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001117915,"about_ca_topic_score_gemma":0.00004157657,"domain_scores_codex":[0.9992464,0.00002708724,0.0001852839,0.0001871749,0.0001656706,0.0001883889],"domain_scores_gemma":[0.9995896,0.000007209393,0.00008008689,0.0002046119,0.00007055351,0.00004789901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005974811,0.0000244587,0.008764437,0.000009052953,0.00005422367,9.271471e-7,0.0003041104,0.00001445897,0.9527806,0.0001058828,0.0007794596,0.03710264],"study_design_scores_gemma":[0.0001931059,0.00006211357,0.04332414,0.00001042585,0.000004471582,0.000008941332,0.00006832865,0.0001333562,0.9497561,0.00009548435,0.006245121,0.0000984164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952555,0.0005705709,0.002645622,0.00002934973,0.00005820851,0.0001468146,0.000004176764,0.000004904151,0.001284905],"genre_scores_gemma":[0.9940476,0.0001002934,0.003409283,0.00008144103,0.00006051475,0.0000222215,0.00006310874,0.00001207055,0.002203463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03700422,"threshold_uncertainty_score":0.2800221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0292477176101967,"score_gpt":0.2647319895886235,"score_spread":0.2354842719784268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}