{"id":"W1981221946","doi":"10.1089/jir.2007.0054","title":"Cigarette Smoke Suppresses Type I Interferon-Mediated Antiviral Immunity in Lung Fibroblast and Epithelial Cells","year":2008,"lang":"en","type":"article","venue":"Journal of Interferon & Cytokine Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research; Philip Morris International","keywords":"STAT1; Interferon; Biology; Sendai virus; Innate immune system; Transcription factor; ISG15; Immunology; Immune system; Virus; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.002082449,0.0003454172,0.0007855146,0.001324987,0.0002759323,0.00006200314,0.0008083479,0.0003896072,0.0007347296],"category_scores_gemma":[0.0009755584,0.0002791338,0.0001779987,0.0005486783,0.001051022,0.0004161198,0.0005815036,0.002806263,0.00015393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002489938,"about_ca_system_score_gemma":0.0003770646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003221561,"about_ca_topic_score_gemma":0.00005520897,"domain_scores_codex":[0.9955628,0.001820204,0.001110317,0.0003343016,0.0002630849,0.0009093203],"domain_scores_gemma":[0.9970459,0.00126893,0.0003071138,0.0004106813,0.0008795494,0.00008784778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01312185,0.0003755444,0.002826618,0.00006961383,0.0002648878,0.0002719266,0.001590795,0.000004391619,0.9691318,0.00002443472,0.01164485,0.0006733423],"study_design_scores_gemma":[0.003261191,0.006520342,0.01603236,0.0006922444,0.00002263494,0.001087106,0.001140299,0.00002985207,0.9616824,0.00001929214,0.009216836,0.0002954183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994082,0.003530518,0.00003325917,0.0004800823,0.0008530542,0.0002445612,0.00005996931,0.0000219867,0.0006945714],"genre_scores_gemma":[0.9955281,0.002483041,0.00002064573,0.00006449613,0.0001145631,0.000005305799,0.00002262807,0.00004606353,0.001715173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01320575,"threshold_uncertainty_score":0.9999661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04369540292714746,"score_gpt":0.3230542885143026,"score_spread":0.2793588855871552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}