{"id":"W1981252527","doi":"10.1139/y00-130","title":"Effect of<i>trans</i>-resveratrol on 7-benzyloxy-4-trifluoromethylcoumarin<i>O</i>-dealkylation catalyzed by human recombinant CYP3A4 and CYP3A5","year":2001,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"CYP3A4; Recombinant DNA; Alkylation; Chemistry; Resveratrol; Stereochemistry; Pharmacology; Catalysis; Biology; Biochemistry; Enzyme; Cytochrome P450; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001796579,0.0004078911,0.0003225167,0.00009731862,0.00009688185,0.000165529,0.0002249534,0.0002613156,0.001025648],"category_scores_gemma":[0.0001925542,0.0001407035,0.0004672835,0.00009873438,0.0001419295,0.0001600152,0.0001053421,0.0003874144,0.0004290808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001469973,"about_ca_system_score_gemma":0.0001536538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001333758,"about_ca_topic_score_gemma":0.001742658,"domain_scores_codex":[0.9998499,0.00006447258,0.0000141057,0.00002314435,0.00001929636,0.00002912855],"domain_scores_gemma":[0.9998935,0.00003526823,0.00002187008,0.00001270911,0.00001785084,0.00001881432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001003289,0.0001134727,0.000153419,0.00008735666,0.00003739148,0.00005426473,0.00003313096,0.0001152093,0.9958907,0.00003930769,0.00008496349,0.00238739],"study_design_scores_gemma":[0.00002624393,0.001322617,0.00145291,0.000005335735,0.00004135157,0.00009627869,0.00001915317,0.000542279,0.9954716,0.000008617696,0.00100832,0.000005289851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993683,0.002932993,0.00101067,0.00008610653,0.00006561675,0.00002686803,0.0001850794,0.00005442399,0.001955319],"genre_scores_gemma":[0.9947771,0.001591159,0.001319834,0.00008623177,0.0000254395,0.00001740438,0.0004887347,0.00001543081,0.001678564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001333758,"threshold_uncertainty_score":0.003431141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02938001970215018,"score_gpt":0.3681678513950691,"score_spread":0.3387878316929189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}