{"id":"W1981255635","doi":"10.1054/bjoc.2001.1776","title":"MDR1 causes resistance to the antitumour drug miltefosine","year":2001,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Cancer Institute; Austrian Science Fund","keywords":"Miltefosine; Vinblastine; P-glycoprotein; Pharmacology; Biology; IC50; Drug resistance; Cancer research; Multiple drug resistance; Molecular biology; In vitro; Chemistry; Immunology; Chemotherapy; Biochemistry; Microbiology; Visceral leishmaniasis; Leishmaniasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003531232,0.0001141238,0.0003342425,0.00007350797,0.0001398561,0.00005307244,0.0002033865,0.00003819579,0.0003961997],"category_scores_gemma":[0.00004272375,0.00008594528,0.0001645986,0.0003158416,0.00005238432,0.0001080164,0.00001097886,0.0002965233,0.00001242023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008200586,"about_ca_system_score_gemma":0.0002130252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001914436,"about_ca_topic_score_gemma":0.01502558,"domain_scores_codex":[0.9986282,0.00002662885,0.0004181342,0.0001367436,0.0005216527,0.0002686497],"domain_scores_gemma":[0.9990702,0.00002007177,0.0001749416,0.0001538103,0.0003719708,0.0002090491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005238056,0.0008510798,0.0647034,0.0005268379,0.0009348475,0.03338953,0.002078986,0.000498604,0.03270449,0.0007211325,0.7134811,0.1448719],"study_design_scores_gemma":[0.00134722,0.00006159912,0.1185947,0.002130503,0.000185344,0.002354927,0.0002259273,0.000001458833,0.005982647,0.0001356629,0.868839,0.0001410258],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.900348,0.07054812,0.000685873,0.02339108,0.001327261,0.0002779231,0.00003078732,0.00002418134,0.003366736],"genre_scores_gemma":[0.9486823,0.01758115,0.0008528611,0.00253486,0.001355208,0.000008840178,0.000001714834,0.00003042349,0.02895266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1553579,"threshold_uncertainty_score":0.8384625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01082683677644481,"score_gpt":0.2723518852755523,"score_spread":0.2615250484991075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}