{"id":"W1981299113","doi":"10.1097/01.jnen.0000235121.98052.54","title":"LRRK2 Expression in Normal and Pathologic Human Brain and in Human Cell Lines","year":2006,"lang":"en","type":"article","venue":"Journal of Neuropathology & Experimental Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":186,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Japan Foundation for Aging and Health; Alzheimer Society","keywords":"Immunocytochemistry; Microglia; Human brain; LRRK2; Biology; Pathology; Cytoplasmic inclusion; Amyotrophic lateral sclerosis; Parkinsonism; Polyclonal antibodies; Neuroglia; Cytoplasm; Molecular biology; Antibody; Parkinson's disease; Cell biology; Neuroscience; Central nervous system; Medicine; Immunology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002436813,0.0003419785,0.0002582149,0.0005670235,0.000276918,0.0004336071,0.000203438,0.0002772255,0.002262997],"category_scores_gemma":[0.0002601207,0.0001543367,0.0001899714,0.0004805823,0.0002594114,0.000171609,0.0001794289,0.0002714397,0.001017291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002434565,"about_ca_system_score_gemma":0.0002982151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001946295,"about_ca_topic_score_gemma":0.002289892,"domain_scores_codex":[0.9996352,0.00006396285,0.00005509789,0.00008149281,0.0001138827,0.0000503429],"domain_scores_gemma":[0.9998689,0.0000278122,0.00001899564,0.00003239894,0.0000345295,0.00001734018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001324856,0.00002879158,0.0006233658,0.00007797928,0.0000186244,0.0003312654,0.0001066521,0.0000579737,0.9967046,0.0002386273,0.0002838009,0.0013958],"study_design_scores_gemma":[0.00008970925,0.0007954059,0.03323089,0.00005837592,0.0001632693,0.01155984,0.0004482974,0.002045632,0.911804,0.0005198414,0.03924805,0.0000367887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9660699,0.009196701,0.01190845,0.0002947362,0.0001379877,0.00007942778,0.005446594,0.0003225488,0.006543703],"genre_scores_gemma":[0.9591324,0.005891464,0.01052076,0.0001025104,0.00005178153,0.0002036099,0.01667754,0.00008150607,0.007338363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002262997,"threshold_uncertainty_score":0.007570505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01308878715251802,"score_gpt":0.2830615962605161,"score_spread":0.269972809107998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}