{"id":"W1981379105","doi":"10.1016/j.cell.2013.08.055","title":"Retinoic Acid Signaling Is Essential for Embryonic Hematopoietic Stem Cell Development","year":2013,"lang":"en","type":"article","venue":"Cell","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":200,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Biology; Cell biology; Wnt signaling pathway; Stem cell; Retinoic acid; Haematopoiesis; Embryonic stem cell; Hematopoietic stem cell; Signal transduction; Endothelial stem cell; Genetics; Cell culture; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001595881,0.0001351394,0.0001136611,0.00003484137,0.0001234556,0.00004955829,0.0003152133,0.0001478051,0.0002967345],"category_scores_gemma":[0.00001540267,0.0001280611,0.00008219502,0.00008971147,0.00007660484,0.000003483053,0.0001503393,0.00008797248,0.0004774618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002363797,"about_ca_system_score_gemma":0.0002103004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003696211,"about_ca_topic_score_gemma":0.000001269369,"domain_scores_codex":[0.9987782,0.0000236022,0.0002108396,0.0003827148,0.0002016487,0.0004029903],"domain_scores_gemma":[0.9992155,0.00002434253,0.00006636725,0.0003406125,0.0001346237,0.0002185336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007907322,0.00007429929,0.00001581431,0.0001067655,0.00001142755,3.670017e-7,0.00006878602,0.000001056133,0.962569,0.000008297432,0.03580255,0.00133375],"study_design_scores_gemma":[0.0003729221,0.00006852482,0.00002778761,0.000007858699,0.00000677905,0.00000120924,0.00009214468,0.00006859792,0.9002563,0.00008417793,0.09886993,0.0001438055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760689,0.0008008818,0.01909558,0.0005821653,0.00005586673,0.0008447811,0.00001088035,0.00002268177,0.002518281],"genre_scores_gemma":[0.9874334,0.00003208061,0.003566338,0.0003536489,0.0001475907,0.0005195765,0.0001355963,0.00003026159,0.00778149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06306738,"threshold_uncertainty_score":0.6136965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01126851334297846,"score_gpt":0.2564607047487951,"score_spread":0.2451921914058167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}