{"id":"W1981379105","doi":"10.1016/j.cell.2013.08.055","title":"Retinoic Acid Signaling Is Essential for Embryonic Hematopoietic Stem Cell Development","year":2013,"lang":"en","type":"article","venue":"Cell","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":200,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Biology; Cell biology; Wnt signaling pathway; Stem cell; Retinoic acid; Haematopoiesis; Embryonic stem cell; Hematopoietic stem cell; Signal transduction; Endothelial stem cell; Genetics; Cell culture; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003448522,0.000447276,0.0003384287,0.0005849247,0.0004868736,0.000854848,0.0003682751,0.0005458832,0.002979282],"category_scores_gemma":[0.0002977716,0.0004280128,0.0003282806,0.0002650536,0.000570643,0.0004250659,0.0004820351,0.001062102,0.001738939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009087555,"about_ca_system_score_gemma":0.0009725458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002025892,"about_ca_topic_score_gemma":0.005605333,"domain_scores_codex":[0.9995986,0.00004650546,0.00004136151,0.00008522916,0.0001597168,0.00006872911],"domain_scores_gemma":[0.9996524,0.0000480123,0.0001192961,0.000051188,0.00005483553,0.00007426107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004447209,0.000003246752,0.0002174899,0.00002587329,0.000002864202,0.00008877456,0.0000114741,0.00002276599,0.99661,0.0007515971,0.0000762797,0.002145181],"study_design_scores_gemma":[0.0000129234,0.00004764808,0.004816149,0.0000152107,0.00002362531,0.0003879061,0.00004154085,0.0002346417,0.9817967,0.0001995102,0.01241679,0.00000729977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.880788,0.02463415,0.04827903,0.002150943,0.0003861057,0.0002023033,0.004540809,0.001740741,0.03727805],"genre_scores_gemma":[0.9532563,0.005726127,0.01670013,0.0002344946,0.00004417151,0.00005731197,0.001715059,0.0002180947,0.02204821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002979282,"threshold_uncertainty_score":0.009966671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01126851334297846,"score_gpt":0.2564607047487951,"score_spread":0.2451921914058167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}