{"id":"W1981420707","doi":"10.1021/jm050155n","title":"Radiosynthesis and Evaluation of [<sup>11</sup>C]-(+)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2<i>H</i>-naphtho[1,2-<i>b</i>][1,4]oxazin-9-ol as a Potential Radiotracer for in Vivo Imaging of the Dopamine D2 High-Affinity State with Positron Emission Tomography","year":2005,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":226,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Chemistry; Dopamine receptor D2; Radiosynthesis; Agonist; Radioligand; Biodistribution; Dopamine; Receptor; Dopamine receptor; In vivo; Ligand (biochemistry); Positron emission tomography; Biochemistry; Neuroscience; In vitro; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001778191,0.0002405848,0.0004499945,0.00008967712,0.00007144479,0.00001563874,0.0002711268,0.0001370295,0.00008569988],"category_scores_gemma":[0.0002347364,0.0001632903,0.0002073794,0.0001610921,0.0001588796,0.00002446122,0.00005277085,0.000240203,4.885666e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005735675,"about_ca_system_score_gemma":0.0002967473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003134273,"about_ca_topic_score_gemma":0.000005288693,"domain_scores_codex":[0.9977908,0.0001355579,0.0007368662,0.0002744172,0.0008016572,0.0002606802],"domain_scores_gemma":[0.9982443,0.00006058585,0.0008038135,0.0002475015,0.0005008212,0.000143003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001034368,0.0001433818,0.002949362,0.0001665307,0.0001152104,0.000006092991,0.0001609437,0.003888458,0.9853784,0.00000127887,0.0001697095,0.005986252],"study_design_scores_gemma":[0.003403796,0.0003624872,0.0006590364,0.0005019868,0.0003373334,0.0004065654,0.0003891962,0.003184889,0.9901679,0.00008183322,0.0003316434,0.0001733651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952657,0.002862943,0.0009934107,0.0004550567,0.00006545591,0.0002740267,0.00002273906,0.000002580425,0.00005810317],"genre_scores_gemma":[0.9972883,0.0002584519,0.00188584,0.00005475,0.0004214986,0.000008589862,0.000008497889,0.00002725469,0.00004678899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005812887,"threshold_uncertainty_score":0.6658784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004942876852272141,"score_gpt":0.2336965804100601,"score_spread":0.228753703557788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}