{"id":"W1981420707","doi":"10.1021/jm050155n","title":"Radiosynthesis and Evaluation of [<sup>11</sup>C]-(+)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2<i>H</i>-naphtho[1,2-<i>b</i>][1,4]oxazin-9-ol as a Potential Radiotracer for in Vivo Imaging of the Dopamine D2 High-Affinity State with Positron Emission Tomography","year":2005,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":226,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Chemistry; Dopamine receptor D2; Radiosynthesis; Agonist; Radioligand; Biodistribution; Dopamine; Receptor; Dopamine receptor; In vivo; Ligand (biochemistry); Positron emission tomography; Biochemistry; Neuroscience; In vitro; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003426294,0.0003960474,0.0002124562,0.0002179522,0.0002431624,0.0003644007,0.0003424929,0.0004498621,0.0008213436],"category_scores_gemma":[0.0002430154,0.0001965031,0.0002293625,0.000155565,0.0003958685,0.0002131664,0.0002131506,0.0003482628,0.0003379967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003881039,"about_ca_system_score_gemma":0.000454309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002140797,"about_ca_topic_score_gemma":0.002534622,"domain_scores_codex":[0.9998757,0.00004433085,0.000005424739,0.00002124744,0.00002542918,0.00002786331],"domain_scores_gemma":[0.9998908,0.000026293,0.0000250577,0.00001376808,0.00002326142,0.00002082416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003577764,0.00004089361,0.0002094269,0.000056739,0.00001014739,0.0001195418,0.00006228418,0.001132438,0.995156,0.0002291799,0.00004368452,0.002581687],"study_design_scores_gemma":[0.00003123672,0.0007148969,0.001045407,0.000005482478,0.00001917025,0.0002510895,0.00003643277,0.0009429631,0.9952727,0.00004105883,0.001627562,0.00001199307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822038,0.002804768,0.01032034,0.0001068784,0.00003076367,0.0001555622,0.0002995908,0.00006388786,0.004014414],"genre_scores_gemma":[0.9830347,0.001960621,0.01130147,0.00006477126,0.00001636764,0.0000754353,0.0005919545,0.00005140709,0.002903201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002140797,"threshold_uncertainty_score":0.004256725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004942876852272141,"score_gpt":0.2336965804100601,"score_spread":0.228753703557788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}