{"id":"W1981501164","doi":"10.1016/j.bbrc.2010.10.081","title":"Hepatitis C virus nonstructural protein-5A activates sterol regulatory element-binding protein-1c through transcription factor Sp1","year":2010,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation","keywords":"NS5A; Transcription factor; Chromatin immunoprecipitation; Sterol regulatory element-binding protein; Sp1 transcription factor; Promoter; Hepatitis C virus; Biology; Steatosis; Molecular biology; Transcription (linguistics); Cancer research; Virology; Gene; Virus; Hepacivirus; Biochemistry; Gene expression; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004611537,0.000712703,0.000376584,0.0007484929,0.0007646289,0.0006511736,0.00028902,0.0003885349,0.004053054],"category_scores_gemma":[0.0005274767,0.0003482988,0.0007639883,0.0002422744,0.0004736829,0.0003960487,0.0007353871,0.001127138,0.001564329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007774897,"about_ca_system_score_gemma":0.0005144599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001583854,"about_ca_topic_score_gemma":0.002264907,"domain_scores_codex":[0.9994683,0.0001217396,0.00002788133,0.00008907155,0.00009316476,0.0001998859],"domain_scores_gemma":[0.9996281,0.00009022139,0.00005201172,0.00004368909,0.00008557049,0.0001005408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008304822,0.0001651499,0.001721177,0.0001426312,0.0000242534,0.0002237504,0.00009422799,0.0001141945,0.9887186,0.0008765932,0.001447037,0.005641868],"study_design_scores_gemma":[0.0002683828,0.000690639,0.05200351,0.00006713763,0.00007233863,0.0009028986,0.0006138738,0.006549367,0.9254618,0.001314292,0.01201497,0.00004067643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709915,0.007742872,0.006984257,0.001274611,0.0008793757,0.0001295136,0.001428432,0.000348582,0.01022094],"genre_scores_gemma":[0.9873033,0.001293761,0.002448919,0.0003415504,0.0001254517,0.00006833887,0.001911801,0.00006793852,0.006438851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004053054,"threshold_uncertainty_score":0.0135588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06386526069255034,"score_gpt":0.3567310812972476,"score_spread":0.2928658206046973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}