{"id":"W1981517535","doi":"10.1039/c2jm15277k","title":"Reducible self-assembled micelles for enhanced intracellular delivery of doxorubicin","year":2012,"lang":"en","type":"article","venue":"Journal of Materials Chemistry","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Micelle; Doxorubicin; Intracellular; Ethylene glycol; Drug delivery; Biophysics; Chemistry; Dithiothreitol; Internalization; Cytotoxicity; Copolymer; Amphiphile; Combinatorial chemistry; Confocal microscopy; In vitro; Materials science; Organic chemistry; Biochemistry; Cell; Aqueous solution; Cell biology; Biology; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001908219,0.0003612054,0.0002270325,0.0001593299,0.0000834054,0.0001992126,0.0002268387,0.0003306123,0.0004440126],"category_scores_gemma":[0.0001659199,0.0001551722,0.000195887,0.00006375626,0.0001109481,0.000355449,0.0001560725,0.0003568311,0.0003280009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000208505,"about_ca_system_score_gemma":0.0001640434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001805973,"about_ca_topic_score_gemma":0.0003813106,"domain_scores_codex":[0.999897,0.00001992031,0.00001159934,0.00002476094,0.00002974227,0.00001690167],"domain_scores_gemma":[0.9999374,0.00001236041,0.00001827916,0.000004664813,0.00001666301,0.00001060047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001892116,0.00001528622,0.00002188097,0.00004225188,0.000003364845,0.00003722735,0.00001621299,0.00009560806,0.9971616,0.0001783938,0.00002204508,0.002387271],"study_design_scores_gemma":[0.0000149331,0.0001267774,0.0001045211,0.000003692422,0.000010887,0.0001032993,0.000004134847,0.001272863,0.9952932,0.00002706164,0.003034211,0.000004322498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9236984,0.01201501,0.06059273,0.0004063036,0.0001344379,0.000177582,0.00009938484,0.0004015405,0.002474547],"genre_scores_gemma":[0.9578991,0.003794051,0.03319566,0.0001355956,0.00003885313,0.00007294681,0.0001712204,0.00005341928,0.00463906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004440126,"threshold_uncertainty_score":0.001512885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0105747685532577,"score_gpt":0.2365554807112243,"score_spread":0.2259807121579666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}