{"id":"W1981523473","doi":"10.2217/fvl.09.29","title":"HCV NS2/3 Protease: A Future Antiviral Drug Target?","year":2009,"lang":"en","type":"article","venue":"Future Virology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Canadian Liver Foundation","keywords":"Protease; NS3; Virology; NS2-3 protease; Viral replication; Drug discovery; Enzyme; Infectivity; Antiviral drug; Biology; Drug development; Drug target; Drug; Computational biology; Virus; Pharmacology; Bioinformatics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003396083,0.0002871529,0.0005410984,0.0002668857,0.0001440908,0.00002265412,0.0002495346,0.0004270789,0.001304957],"category_scores_gemma":[0.0001034461,0.00023153,0.0001648208,0.0004240422,0.0001370975,0.0001245856,0.00006198576,0.001056197,0.0008523405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008158141,"about_ca_system_score_gemma":0.0002266465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002772869,"about_ca_topic_score_gemma":0.00004205051,"domain_scores_codex":[0.9976193,0.0002468561,0.0003165427,0.0005417886,0.0004757682,0.0007996883],"domain_scores_gemma":[0.9988473,0.00003174687,0.00007668704,0.0006215049,0.0001269532,0.0002958172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00288144,0.001266431,0.07718585,0.0002188764,0.0002409643,0.004206307,0.002250264,0.000002891076,0.05074311,0.006333444,0.4270364,0.427634],"study_design_scores_gemma":[0.001724,0.0009426228,0.1075327,0.00001878859,0.00003440031,0.00008049099,0.00009688213,0.0001119211,0.002039751,0.0005721455,0.8866246,0.0002216439],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7589983,0.004190279,0.0002164686,0.1697052,0.002085522,0.00243582,0.0000811478,0.0005105727,0.06177671],"genre_scores_gemma":[0.9712037,0.0003875089,0.003042887,0.009633369,0.01063369,0.00006951229,0.0001186062,0.00004864932,0.004862101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4595882,"threshold_uncertainty_score":0.9999256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008342611826541484,"score_gpt":0.2924454897684865,"score_spread":0.284102877941945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}