{"id":"W1981533302","doi":"10.1038/nchembio.643","title":"High-frequency transposition for determining antibacterial mode of action","year":2011,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Transposable element; Biology; Staphylococcus aureus; Mode of action; Efflux; Bacteriophage; Genetics; Transposition (logic); Microbiology; Transposon mutagenesis; Mutant; Escherichia coli; Computational biology; Gene; Bacteria; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001171423,0.000682298,0.0006257289,0.000960578,0.0004778596,0.0007674525,0.0006982174,0.001136389,0.002806177],"category_scores_gemma":[0.001890113,0.0007673791,0.0005136046,0.0005594896,0.0007013906,0.0005030705,0.0006600014,0.00222486,0.0009232641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009186705,"about_ca_system_score_gemma":0.0005002798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001046162,"about_ca_topic_score_gemma":0.002677799,"domain_scores_codex":[0.9984683,0.000619178,0.00014149,0.0003190147,0.0002717174,0.0001801565],"domain_scores_gemma":[0.9978352,0.001277617,0.0002090065,0.000343042,0.0001659542,0.0001692472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008795314,0.00006419778,0.000189162,0.0000175086,0.00000424701,0.00001444387,0.00002091275,0.00009080047,0.9972188,0.0002783303,0.00002776517,0.001985739],"study_design_scores_gemma":[0.00002884984,0.0002180613,0.001386248,0.000008148995,0.00002416785,0.0001132741,0.00002593556,0.002655127,0.9947431,0.0001212658,0.0006604194,0.00001545941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9391536,0.000526864,0.05499101,0.0002425033,0.00009552138,0.000404985,0.0006263014,0.0005486772,0.003410581],"genre_scores_gemma":[0.9456318,0.0003101784,0.04996062,0.0001283894,0.00001713182,0.0001832489,0.0006516805,0.0002468744,0.002870015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002806177,"threshold_uncertainty_score":0.009387612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01628890364475927,"score_gpt":0.2794224295923743,"score_spread":0.263133525947615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}