{"id":"W1981534902","doi":"10.1016/s0378-1119(03)00737-6","title":"A single amino acid substitution in MSH5 results in DNA alkylation tolerance","year":2003,"lang":"en","type":"article","venue":"Gene","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; University of Manitoba","keywords":"Biology; Gene; DNA repair; Mutation; Mutant; Genetics; DNA; Point mutation; Saccharomyces cerevisiae; Alkylation; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002219971,0.00009558841,0.0001575341,0.0001234055,0.0000169733,0.000006566103,0.00003898653,0.00009518252,0.00005685544],"category_scores_gemma":[0.0002993503,0.00009705299,0.00002464125,0.0003625829,0.00003404829,0.00004383822,0.000007026824,0.0001174996,0.00003139939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003234504,"about_ca_system_score_gemma":0.00009400086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005290558,"about_ca_topic_score_gemma":0.0004994795,"domain_scores_codex":[0.9990513,0.00004707107,0.0002720586,0.0002451315,0.0001760289,0.0002084011],"domain_scores_gemma":[0.9996344,0.00002243906,0.00004900068,0.0002067612,0.00003964085,0.00004774496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003931865,0.000150681,0.02976748,0.00002362805,0.00000387138,0.00003799873,0.0005380454,0.0007634092,0.9626583,0.00005656291,0.000163101,0.005443688],"study_design_scores_gemma":[0.002234593,0.0001813393,0.197211,0.00007197235,0.000005985489,0.00002074314,0.0000239381,0.0001698166,0.7949165,0.0001243727,0.004941662,0.00009801186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892641,0.0007338169,0.0001376628,0.0001840253,0.0003575922,0.000299954,0.000004670547,0.00002138675,0.008996796],"genre_scores_gemma":[0.9975113,0.00003570984,0.001936706,0.0001558165,0.00006011845,0.00002566342,0.00002259238,0.00001024067,0.0002418559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1677418,"threshold_uncertainty_score":0.3957706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02877044697936608,"score_gpt":0.2641773299606233,"score_spread":0.2354068829812572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}