{"id":"W1981541499","doi":"10.1074/jbc.m201981200","title":"A de Novo Designed Template for Generating Conformation-specific Antibodies That Recognize α-Helices in Proteins","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Alberta","keywords":"Polyclonal antibodies; Antibody; Coiled coil; Peptide; Antigen; Helix (gastropod); Chemistry; Peptide sequence; Protein structure; Sequence (biology); Biochemistry; Biophysics; Biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002719722,0.0004489952,0.0003616771,0.0002741411,0.0001422389,0.0002748621,0.0004521178,0.0004564675,0.0006230655],"category_scores_gemma":[0.0004053983,0.0003366179,0.0004248729,0.0002558656,0.0001742191,0.0001907453,0.0002005656,0.0006563731,0.0006788413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000304058,"about_ca_system_score_gemma":0.0003865584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003436884,"about_ca_topic_score_gemma":0.0006348063,"domain_scores_codex":[0.9997041,0.00003975285,0.0000337813,0.00007932835,0.0001003921,0.00004279154],"domain_scores_gemma":[0.9998021,0.0000317011,0.00005883291,0.00003223283,0.00003804966,0.00003719229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003037026,0.00003635327,0.0001309491,0.0000517218,0.000006939294,0.00008047753,0.00001668776,0.0005106884,0.9963044,0.0002219408,0.00006130289,0.002548262],"study_design_scores_gemma":[0.00001672294,0.000214539,0.0005008783,0.00000671668,0.00001461978,0.0002517799,0.000008061707,0.002607101,0.9918309,0.00006835924,0.004471687,0.000008674854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.6904633,0.001905271,0.2980467,0.0003051102,0.0002909492,0.001026943,0.0019106,0.001232211,0.004818866],"genre_scores_gemma":[0.7372168,0.001353057,0.2513412,0.0002219714,0.00004747121,0.0005429462,0.003278888,0.0001654682,0.005832273],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0006230655,"threshold_uncertainty_score":0.002206087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1409541198097821,"score_gpt":0.3293208528156277,"score_spread":0.1883667330058456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}