{"id":"W1981558347","doi":"10.1002/anie.200903747","title":"Functional Profiling, Identification, and Inhibition of Plasmepsins in Intraerythrocytic Malaria Parasites","year":2009,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Malaria Research and Control","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Malaria; Vacuole; Identification (biology); Computational biology; Biology; Profiling (computer programming); Proteases; Biochemistry; Immunology; Computer science; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001334461,0.0002560162,0.0001576771,0.000138799,0.00007954016,0.000145633,0.0001474964,0.0002074418,0.0004815861],"category_scores_gemma":[0.0001276659,0.0001377276,0.0001130583,0.00009640273,0.0001148775,0.0001191397,0.00009166779,0.0002639802,0.00023349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001291517,"about_ca_system_score_gemma":0.00009179795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002746052,"about_ca_topic_score_gemma":0.0005415933,"domain_scores_codex":[0.9999174,0.00001649937,0.000007948831,0.0000148681,0.00002397742,0.00001934658],"domain_scores_gemma":[0.9999456,0.00001309843,0.00001387072,0.00000809777,0.000009803171,0.000009499448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003092051,0.000004699904,0.00005330372,0.000006584708,6.868532e-7,0.000007258453,0.000003247147,0.00002037276,0.9994183,0.00001318791,0.000008739392,0.0004327253],"study_design_scores_gemma":[0.000003658569,0.00008841613,0.001762092,0.000001008817,0.000003941659,0.00007464588,0.000006838485,0.0003452224,0.9972857,0.000006266949,0.0004213129,9.165423e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951134,0.0006223005,0.003097623,0.00006801866,0.000005905076,0.00001975853,0.0002224566,0.00002885331,0.000821617],"genre_scores_gemma":[0.9930205,0.0007495586,0.003490548,0.0000401172,0.000004195489,0.00003126716,0.000489829,0.00001318313,0.002160853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004815861,"threshold_uncertainty_score":0.001611054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0159464814637223,"score_gpt":0.2806753108604856,"score_spread":0.2647288293967633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}