{"id":"W1981558347","doi":"10.1002/anie.200903747","title":"Functional Profiling, Identification, and Inhibition of Plasmepsins in Intraerythrocytic Malaria Parasites","year":2009,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Malaria Research and Control","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Malaria; Vacuole; Identification (biology); Computational biology; Biology; Profiling (computer programming); Proteases; Biochemistry; Immunology; Computer science; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002107092,0.00008995004,0.0001437943,0.0002222246,0.00002765486,0.00002604076,0.00003976407,0.0000833069,0.000250081],"category_scores_gemma":[0.0002998147,0.0000880825,0.00004359107,0.0001370684,0.00006040279,0.000254552,0.00001233398,0.0001550299,0.000009960737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001079612,"about_ca_system_score_gemma":0.00007775164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001624947,"about_ca_topic_score_gemma":0.000008694056,"domain_scores_codex":[0.9989625,0.00001412247,0.0003166345,0.0002045315,0.0003757064,0.0001264631],"domain_scores_gemma":[0.9993899,0.00005080175,0.0001059222,0.00009223882,0.0002935833,0.00006755558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006439109,0.00031708,0.008774793,0.00005055962,0.00004522484,0.00001923984,0.0000695618,0.0000108555,0.9714523,0.0147536,0.002532841,0.001330031],"study_design_scores_gemma":[0.001570089,0.0001049594,0.3000793,0.00007640506,0.00001740316,0.00003484015,0.00004552738,0.0003577399,0.6933836,0.004142048,0.000131233,0.00005693737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9664702,0.0001769072,0.006429615,0.02158387,0.0003875362,0.0005130775,0.00008470878,0.00004815083,0.004305894],"genre_scores_gemma":[0.9975637,0.00009563909,0.0002963804,0.0002656365,0.0004811147,0.00003464476,0.0009458392,0.000005842119,0.0003112576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2913044,"threshold_uncertainty_score":0.35919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0159464814637223,"score_gpt":0.2806753108604856,"score_spread":0.2647288293967633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}