{"id":"W1981585437","doi":"10.1016/j.bmcl.2006.01.122","title":"Anti-Plasmodium activity of imidazole–dioxolane compounds","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Malaria Research and Control","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Plasmodium falciparum; Chemistry; Chinese hamster ovary cell; Heme; Dioxolane; Mechanism of action; Chloroquine; Biochemistry; In vitro; Inhibitory postsynaptic potential; Hemozoin; Receptor; Biology; Enzyme; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001004869,0.0002057613,0.0001914194,0.0001809451,0.0001355774,0.0001510259,0.0002571346,0.000136764,0.003584452],"category_scores_gemma":[0.00008609674,0.00007597783,0.00007926349,0.0001121426,0.000101405,0.0001173955,0.00008647647,0.0002667247,0.0003286698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001451675,"about_ca_system_score_gemma":0.0001037016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004102904,"about_ca_topic_score_gemma":0.0006540474,"domain_scores_codex":[0.9999621,0.000007615987,0.000003042157,0.000004992215,0.000005971059,0.00001620991],"domain_scores_gemma":[0.9999678,0.000006497671,0.000007166275,0.000002727071,0.00000540363,0.00001049205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001198958,0.0001886904,0.0002153831,0.0002262299,0.00001448978,0.0001827049,0.00004688703,0.0003064316,0.9804752,0.0004618207,0.0005239266,0.01615921],"study_design_scores_gemma":[0.0001766335,0.003382532,0.002271368,0.00002018514,0.0000364964,0.000364824,0.00002788135,0.000671069,0.9840724,0.00007645244,0.008889106,0.00001097176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827031,0.006831593,0.001057635,0.0001903459,0.00007778803,0.00003673357,0.0002528583,0.00009348649,0.008756419],"genre_scores_gemma":[0.9903761,0.003111729,0.0009961835,0.00009762328,0.00004290334,0.00001531806,0.0003380507,0.000007070216,0.005015107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003584452,"threshold_uncertainty_score":0.01199114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008643519587933733,"score_gpt":0.233502497650003,"score_spread":0.2248589780620692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}