{"id":"W1981585437","doi":"10.1016/j.bmcl.2006.01.122","title":"Anti-Plasmodium activity of imidazole–dioxolane compounds","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Malaria Research and Control","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Plasmodium falciparum; Chemistry; Chinese hamster ovary cell; Heme; Dioxolane; Mechanism of action; Chloroquine; Biochemistry; In vitro; Inhibitory postsynaptic potential; Hemozoin; Receptor; Biology; Enzyme; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002692055,0.0002466777,0.0005811314,0.00006264682,0.00006203949,0.00001398089,0.0002242278,0.0001442175,0.0008566211],"category_scores_gemma":[0.0001307389,0.0002112655,0.0001416131,0.0002556822,0.0003098559,0.00005333561,0.00005487687,0.0004575166,0.00002759848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001341478,"about_ca_system_score_gemma":0.0002081976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003204328,"about_ca_topic_score_gemma":0.000003278692,"domain_scores_codex":[0.997973,0.00003274072,0.0003471645,0.0003590603,0.0007791356,0.0005088586],"domain_scores_gemma":[0.9989121,0.00009809582,0.0001557567,0.0004686463,0.0001060239,0.0002593629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003948051,0.0002292001,0.005626199,0.0003954284,0.00009147895,0.0002143981,0.0000152571,0.000001200157,0.982191,0.00001705525,0.01055309,0.0002709457],"study_design_scores_gemma":[0.002821244,0.00007484158,0.07997305,0.0001494302,0.0001422057,0.0003390067,0.00003416301,0.0001043432,0.9146472,0.000009097271,0.001521181,0.0001842646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709856,0.0002417815,0.000340858,0.02361871,0.00009265578,0.0002243017,0.00002128876,0.00007261415,0.004402186],"genre_scores_gemma":[0.9980317,0.00001641746,0.0000980882,0.0005931479,0.0008298355,0.00000933159,0.00006176683,0.0000289018,0.0003308259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07434686,"threshold_uncertainty_score":0.93794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008643519587933733,"score_gpt":0.233502497650003,"score_spread":0.2248589780620692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}