{"id":"W1981587077","doi":"10.1016/j.semcancer.2015.03.005","title":"Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition","year":2015,"lang":"en","type":"review","venue":"Seminars in Cancer Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":333,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Institute of Dental and Craniofacial Research; National Cancer Institute; National Center for Complementary and Integrative Health; National Institute on Aging; Canadian Institutes of Health Research; Università degli Studi di Firenze; National Institutes of Health; Terry Fox Foundation; United Arab Emirates University; Ministry of Education, Culture, Sports, Science and Technology; Universitetet i Oslo; Ministero dell’Istruzione, dell’Università e della Ricerca; Breast Cancer Research Trust; Avon Foundation for Women; Cancer Research UK; University of Rochester; Center for Hierarchical Manufacturing, National Science Foundation; Child and Family Research Institute; U.S. Public Health Service; U.S. Department of Defense; Associazione Italiana per la Ricerca sul Cancro; Eli Lilly and Company; Bristol-Myers Squibb; National Institute of Diabetes and Digestive and Kidney Diseases; Department of Biology, Indiana State University; Verein fur Krebsforschung; Uniting Against Lung Cancer; Elsa U. Pardee Foundation; University of Glasgow; Susan G. Komen for the Cure","keywords":"Genome instability; Biology; DNA damage; Chromosome instability; Cancer; DNA repair; Epigenetics; Telomere; Microsatellite instability; Centrosome; Cancer research; Genetics; Computational biology; Bioinformatics; DNA; Gene; Cell cycle; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003548421,0.0005913044,0.0008599103,0.00150273,0.0002650139,0.0007111114,0.0006225304,0.001029871,0.002682394],"category_scores_gemma":[0.0003729828,0.0001699828,0.0003384734,0.00138425,0.0005104747,0.0009601356,0.0006000097,0.001670573,0.001551924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006990966,"about_ca_system_score_gemma":0.0008197278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008695651,"about_ca_topic_score_gemma":0.001255405,"domain_scores_codex":[0.9998989,0.00001836945,0.00001265753,0.00001894634,0.00003708255,0.00001400407],"domain_scores_gemma":[0.999877,0.00004770743,0.00001479744,0.000006456401,0.00003655875,0.00001747301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007751818,0.00007794947,0.0002131279,0.01147285,0.00007137225,0.0002964759,0.00008344881,0.0004073062,0.005053869,0.008190984,0.02801212,0.9460429],"study_design_scores_gemma":[0.0000115935,0.00008437168,0.0008903581,0.00193274,0.00005352419,0.001378803,0.00007052234,0.0000771202,0.001063038,0.003619145,0.9908023,0.00001644133],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001465378,0.998139,0.0001840946,0.0003618755,0.0001754058,0.000002928144,0.00001287972,0.000008520075,0.0009686314],"genre_scores_gemma":[0.0008443558,0.9981141,0.0001971605,0.0001385417,0.00009889856,0.000004500579,0.0000200363,0.000001462991,0.0005808947],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002682394,"threshold_uncertainty_score":0.008973479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1162425379905104,"score_gpt":0.401577689317901,"score_spread":0.2853351513273906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}