{"id":"W1981587077","doi":"10.1016/j.semcancer.2015.03.005","title":"Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition","year":2015,"lang":"en","type":"review","venue":"Seminars in Cancer Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":333,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Institute of Dental and Craniofacial Research; National Cancer Institute; National Center for Complementary and Integrative Health; National Institute on Aging; Canadian Institutes of Health Research; Università degli Studi di Firenze; National Institutes of Health; Terry Fox Foundation; United Arab Emirates University; Ministry of Education, Culture, Sports, Science and Technology; Universitetet i Oslo; Ministero dell’Istruzione, dell’Università e della Ricerca; Breast Cancer Research Trust; Avon Foundation for Women; Cancer Research UK; University of Rochester; Center for Hierarchical Manufacturing, National Science Foundation; Child and Family Research Institute; U.S. Public Health Service; U.S. Department of Defense; Associazione Italiana per la Ricerca sul Cancro; Eli Lilly and Company; Bristol-Myers Squibb; National Institute of Diabetes and Digestive and Kidney Diseases; Department of Biology, Indiana State University; Verein fur Krebsforschung; Uniting Against Lung Cancer; Elsa U. Pardee Foundation; University of Glasgow; Susan G. Komen for the Cure","keywords":"Genome instability; Biology; DNA damage; Chromosome instability; Cancer; DNA repair; Epigenetics; Telomere; Microsatellite instability; Centrosome; Cancer research; Genetics; Computational biology; Bioinformatics; DNA; Gene; Cell cycle; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003206427,0.0003396506,0.0008354259,0.0001055799,0.00004563985,0.00001559894,0.0001255161,0.0006222578,0.000003291183],"category_scores_gemma":[0.00001291132,0.0003168637,0.00008016085,0.00006392219,0.0002635099,0.000008785987,0.0001842649,0.0001631261,6.298858e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001508935,"about_ca_system_score_gemma":0.0002535609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000127394,"about_ca_topic_score_gemma":0.0008748186,"domain_scores_codex":[0.9982435,0.0002971483,0.0004283167,0.0007177577,0.00004618158,0.0002671359],"domain_scores_gemma":[0.9994013,0.0000286148,0.0002116649,0.000251421,0.00004967075,0.00005733212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00018239,0.0001103031,0.0002428322,0.008100172,0.0001548148,0.000007149732,0.0002337403,9.711941e-7,0.01255776,0.0007210297,0.0001143634,0.9775745],"study_design_scores_gemma":[0.001052695,0.001532314,0.00002309631,0.003113716,0.0001953924,0.00001989147,0.0001535696,0.000007270929,0.001059361,0.008512791,0.9838479,0.0004820667],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.144216,0.8540165,0.00004126717,0.00004493588,0.0001213193,0.001348252,0.0001658434,0.000006679281,0.00003915812],"genre_scores_gemma":[0.009042579,0.9881588,0.0002839397,0.00008437238,0.00008819959,0.001728851,0.0005136188,0.00004003584,0.00005961465],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9837335,"threshold_uncertainty_score":0.9999284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1162425379905104,"score_gpt":0.401577689317901,"score_spread":0.2853351513273906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}