{"id":"W1981601846","doi":"10.1016/j.smim.2009.05.006","title":"The innate immune response to DNA","year":2009,"lang":"en","type":"review","venue":"Seminars in Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"AIM2; Innate immune system; TLR9; Inflammasome; Biology; DNA; Toll-Like Receptor 9; Pattern recognition receptor; Immune system; Cell biology; Receptor; Immunology; Genetics; Gene; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003270004,0.0007396485,0.00202031,0.001001243,0.0005022067,0.00006844052,0.001636481,0.001631245,0.0001191803],"category_scores_gemma":[0.00170597,0.0005376586,0.0005414963,0.0009976965,0.0004510497,0.00009913471,0.0005085016,0.001661906,0.004542426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003977574,"about_ca_system_score_gemma":0.0005947932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003138814,"about_ca_topic_score_gemma":0.00001450413,"domain_scores_codex":[0.992141,0.004216902,0.001713438,0.0006880923,0.00006859281,0.001171991],"domain_scores_gemma":[0.9954531,0.002218739,0.0005904072,0.001620897,0.0000923158,0.00002459155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002118933,0.00006100393,2.632472e-7,0.0001555096,0.0003198149,0.00004201615,0.0003042299,5.239552e-7,0.01123677,0.0003702216,0.002694984,0.9826957],"study_design_scores_gemma":[0.0005777345,0.0006525766,0.0001124266,0.005750755,0.0001339293,0.0005815739,0.0001602546,7.064015e-8,0.001573954,0.00009738679,0.9898181,0.0005412548],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002072139,0.9929533,0.000005483469,0.0006244035,0.00232255,0.001365187,0.00001116893,0.00009409905,0.0005516464],"genre_scores_gemma":[0.00008131983,0.9819568,0.00003031902,0.00009369881,0.00004286831,0.0003832258,0.0002145272,0.00007644534,0.01712075],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9871231,"threshold_uncertainty_score":0.9997075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01393118216937973,"score_gpt":0.2911240284906503,"score_spread":0.2771928463212706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}