{"id":"W1981631249","doi":"10.1158/1078-0432.ccr-05-0429","title":"Intermittent Exposure of Primitive Quiescent Chronic Myeloid Leukemia Cells to Granulocyte-Colony Stimulating Factor <i>In vitro</i> Promotes their Elimination by Imatinib Mesylate","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Imatinib mesylate; Medicine; Myeloid leukemia; Granulocyte colony-stimulating factor; Imatinib; Mesylate; Pharmacology; CD34; Leukemia; Haematopoiesis; Immunology; Chemotherapy; Internal medicine; Stem cell; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001872293,0.00035591,0.0009818861,0.0002962108,0.0001122247,0.00003776627,0.0003575161,0.000307625,0.0002384931],"category_scores_gemma":[0.0007087557,0.0002891173,0.0002693311,0.0006798652,0.000377498,0.0001178408,0.0003000911,0.001234854,0.00005458204],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007817077,"about_ca_system_score_gemma":0.002302455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002564217,"about_ca_topic_score_gemma":0.0005036325,"domain_scores_codex":[0.9948091,0.0005987374,0.001537471,0.0009178137,0.001157644,0.0009792183],"domain_scores_gemma":[0.996609,0.001521113,0.000299649,0.0006479534,0.0005996088,0.0003226442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003374211,0.001305075,0.04262607,0.0007822068,0.0001782626,0.00007197278,0.0009589562,0.0002723563,0.7682173,0.0000175516,0.003366378,0.1788296],"study_design_scores_gemma":[0.009290663,0.003297084,0.2045988,0.00125748,0.00005601914,0.000004367841,0.0001790652,0.002881616,0.7764578,0.00005478176,0.001604481,0.0003178299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930871,0.001455816,0.00005556443,0.001281212,0.0002298596,0.003086881,0.0002473258,0.00005302718,0.0005032897],"genre_scores_gemma":[0.996983,0.0003973644,0.0003918422,0.0001285128,0.0003977558,0.000482284,0.0001354165,0.00007208599,0.00101177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1785118,"threshold_uncertainty_score":0.9999561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.073390416314338,"score_gpt":0.4188013356411297,"score_spread":0.3454109193267917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}