{"id":"W1981642316","doi":"10.1002/iub.194","title":"Nuclear localization signals and human disease","year":2009,"lang":"en","type":"review","venue":"IUBMB Life","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"Tellabs (Canada)","funders":"","keywords":"Nuclear transport; Nuclear pore; Nucleoporin; Cell biology; Cytoplasm; Transport protein; Nucleus; Compartment (ship); Nuclear export signal; Ran; Nuclear protein; Protein targeting; Biology; Cell nucleus; Importin; Nuclear localization sequence; Nuclear lamina; Genetics; Membrane protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005346169,0.0002102288,0.0003488147,0.00004229608,0.0001011815,0.00004259547,0.00009521936,0.0002485458,0.00006044313],"category_scores_gemma":[0.00004082512,0.000180585,0.0001423462,0.0000574498,0.00004027478,0.000002343607,0.00005352088,0.00009264339,0.00002754839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008706038,"about_ca_system_score_gemma":0.00005571661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002690658,"about_ca_topic_score_gemma":0.000001069417,"domain_scores_codex":[0.9991812,0.00006223132,0.000208317,0.0003337008,0.00008339835,0.0001311585],"domain_scores_gemma":[0.9994166,0.000003343721,0.0001159749,0.0002648971,0.00002636693,0.0001728309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003050933,0.00004587466,0.00002105107,0.003112348,0.0001608278,0.00001062162,0.00001093581,0.000005462442,0.0002070671,0.0008840032,0.04717584,0.9483355],"study_design_scores_gemma":[0.00008210896,0.00008900166,0.00003463713,0.0003441499,0.0002363312,0.000006110044,0.000001947975,0.000003043317,0.000002616608,0.00007036598,0.9989254,0.0002042557],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009056549,0.9986975,0.0001073272,0.00001915167,0.000102544,0.0002182193,0.00002139568,0.0000204632,0.0007228131],"genre_scores_gemma":[0.0007073937,0.9969058,0.00002901982,0.0006746728,0.0007208263,0.000005634023,0.0005424459,0.00004866286,0.0003655374],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9517496,"threshold_uncertainty_score":0.7364044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01816437674491879,"score_gpt":0.2915702942855915,"score_spread":0.2734059175406727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}