{"id":"W1981642316","doi":"10.1002/iub.194","title":"Nuclear localization signals and human disease","year":2009,"lang":"en","type":"review","venue":"IUBMB Life","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"Tellabs (Canada)","funders":"","keywords":"Nuclear transport; Nuclear pore; Nucleoporin; Cell biology; Cytoplasm; Transport protein; Nucleus; Compartment (ship); Nuclear export signal; Ran; Nuclear protein; Protein targeting; Biology; Cell nucleus; Importin; Nuclear localization sequence; Nuclear lamina; Genetics; Membrane protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000508968,0.0008197047,0.001264449,0.001526439,0.0004120065,0.001049352,0.001030178,0.001802829,0.006275779],"category_scores_gemma":[0.000573498,0.0002090403,0.0003222399,0.0018259,0.001511474,0.001027638,0.000941703,0.001416849,0.004548494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00112333,"about_ca_system_score_gemma":0.001022712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001628184,"about_ca_topic_score_gemma":0.001968919,"domain_scores_codex":[0.9997961,0.00004460852,0.00003078089,0.00004202136,0.00006010203,0.00002648339],"domain_scores_gemma":[0.9997916,0.00009198176,0.00003443305,0.00001270935,0.00004761173,0.00002171487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006850184,0.0000441645,0.0003455258,0.004778577,0.00005240809,0.001138167,0.00010852,0.0002974123,0.001332236,0.01196269,0.05759325,0.9222785],"study_design_scores_gemma":[0.00001297038,0.00002522372,0.0004963755,0.001097494,0.00002377134,0.004596608,0.00004668596,0.00003393002,0.0003445943,0.003049249,0.9902629,0.00001026987],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001343132,0.9963904,0.0001913357,0.0005447094,0.0003896671,0.00000367497,0.00001931053,0.00001122815,0.00231537],"genre_scores_gemma":[0.002132729,0.9941188,0.0002529448,0.0006139736,0.0003908332,0.00001041736,0.00006281259,0.000003028519,0.002414519],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006275779,"threshold_uncertainty_score":0.02099454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01816437674491879,"score_gpt":0.2915702942855915,"score_spread":0.2734059175406727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}