{"id":"W1981643696","doi":"10.1002/cbic.200900750","title":"Structural Investigation of the Binding of 5‐Substituted Swainsonine Analogues to Golgi α‐Mannosidase II","year":2010,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; University of Toronto; Ontario Institute for Cancer Research","funders":"National Center for Research Resources; Division of Materials Research; Canadian Institutes of Health Research; National Institutes of Health; National Science Foundation","keywords":"Swainsonine; Mannosidase; Golgi apparatus; Chemistry; Enzyme; Stereochemistry; Active site; Glycoside hydrolase; Binding site; Glycosylation; Biochemistry; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001098435,0.0001822439,0.0002529612,0.00003967671,0.0001175964,0.00001263188,0.0004261039,0.0001876082,0.0003573316],"category_scores_gemma":[0.0004213234,0.0001458721,0.0001459264,0.0003636732,0.0002521377,0.00006023408,0.0001782681,0.0002481486,0.00000332176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003171013,"about_ca_system_score_gemma":0.00006858169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003851226,"about_ca_topic_score_gemma":0.0000172533,"domain_scores_codex":[0.9989502,0.000007160782,0.0003582282,0.0002590762,0.0002271599,0.0001981346],"domain_scores_gemma":[0.9988397,0.00006382462,0.0002353416,0.0006062259,0.0001362186,0.0001186502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001821716,0.00001592835,0.005191652,0.0001729361,0.0000324395,8.211478e-7,0.0005514945,0.000006263349,0.9935547,0.0001034755,0.000192357,0.000159718],"study_design_scores_gemma":[0.0002246304,0.000005122968,0.001778724,0.000100667,0.00003992292,0.000006365921,0.0001502038,0.00006995105,0.9972333,0.00009570164,0.0001347112,0.0001606661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967301,0.00002490167,9.239983e-7,0.0002375004,0.0001234817,0.00006142782,0.00008484735,0.00003577233,0.00270103],"genre_scores_gemma":[0.9988983,0.000001393555,0.0002402705,0.00002413987,0.0001373038,0.00001052218,0.00007264099,0.00001670724,0.0005987421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003678636,"threshold_uncertainty_score":0.5948491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01276855327197748,"score_gpt":0.2168653964432348,"score_spread":0.2040968431712573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}