{"id":"W1981652396","doi":"10.1021/jm200532b","title":"Inhibitors of Androgen Receptor Activation Function-2 (AF2) Site Identified through Virtual Screening","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Androgen receptor; Virtual screening; Androgen; Function (biology); Receptor; Pharmacology; Endocrinology; Internal medicine; Biochemistry; Cell biology; Drug discovery; Hormone; Prostate cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003814606,0.001112023,0.001375146,0.0007909759,0.0002860459,0.0007047031,0.000622955,0.0003680043,0.001975447],"category_scores_gemma":[0.0004259875,0.0002164557,0.0006280719,0.0005891641,0.0002464503,0.0003064683,0.0005008323,0.0005669446,0.0002794109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000464862,"about_ca_system_score_gemma":0.0005063969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009089135,"about_ca_topic_score_gemma":0.001706113,"domain_scores_codex":[0.9997672,0.00007307354,0.0000110121,0.00003313625,0.00006977801,0.00004584152],"domain_scores_gemma":[0.9999071,0.00004331792,0.0000155074,0.00000614295,0.00001040869,0.00001748951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.004187359,0.00294094,0.008639531,0.001839588,0.001148264,0.001587716,0.000134802,0.427578,0.3496685,0.009117991,0.008001166,0.1851561],"study_design_scores_gemma":[0.002218236,0.008141858,0.005886484,0.0001219087,0.001260154,0.001924424,0.0001401759,0.5662965,0.3784701,0.004557024,0.03080598,0.0001773196],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.936021,0.00889037,0.03451985,0.0004806702,0.0001304087,0.0006771733,0.001994137,0.001451041,0.01583531],"genre_scores_gemma":[0.9805725,0.003042049,0.01237752,0.0001447296,0.00001534198,0.0001722087,0.001565889,0.00003624089,0.00207352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001975447,"threshold_uncertainty_score":0.006608546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04752172691126391,"score_gpt":0.3009524952172191,"score_spread":0.2534307683059551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}