{"id":"W1981652396","doi":"10.1021/jm200532b","title":"Inhibitors of Androgen Receptor Activation Function-2 (AF2) Site Identified through Virtual Screening","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Androgen receptor; Virtual screening; Androgen; Function (biology); Receptor; Pharmacology; Endocrinology; Internal medicine; Biochemistry; Cell biology; Drug discovery; Hormone; Prostate cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003770877,0.0001219102,0.0003262778,0.00006795346,0.00004894472,0.000005718531,0.00008564691,0.0001149332,0.001196002],"category_scores_gemma":[0.0001509089,0.00008718924,0.0001475902,0.000196957,0.0001376977,0.0002090527,0.00002691638,0.0003927425,0.000005614966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009637144,"about_ca_system_score_gemma":0.0002494907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003536322,"about_ca_topic_score_gemma":2.106251e-7,"domain_scores_codex":[0.9984742,0.00002145666,0.0005060367,0.0001244763,0.0006975958,0.0001762788],"domain_scores_gemma":[0.9987541,0.00005329486,0.0004491679,0.0001381118,0.0004323886,0.0001728635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007160126,0.0003766565,0.02820714,0.0003080591,0.000694528,0.0001138793,0.003106492,0.000001696739,0.9384066,0.000009281013,0.009990863,0.01162466],"study_design_scores_gemma":[0.003627454,0.001028763,0.006347184,0.0009391273,0.0002587069,0.0001672766,0.003064287,0.000003976819,0.9825017,0.00005250146,0.001928117,0.00008087434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939672,0.0009523506,0.000905711,0.0003252073,0.0002713653,0.00009573506,0.000004633137,0.000009077468,0.003468665],"genre_scores_gemma":[0.9964311,0.0002010796,0.0005833651,0.00006041447,0.0008688304,0.0000028482,0.00002196368,0.00001525524,0.00181521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04409511,"threshold_uncertainty_score":0.9997171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04752172691126391,"score_gpt":0.3009524952172191,"score_spread":0.2534307683059551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}