{"id":"W1981661830","doi":"10.1016/s0006-3495(03)74654-2","title":"Novel Interactions Identified between μ-Conotoxin and the Na+ Channel Domain I P-loop: Implications for Toxin-Pore Binding Geometry","year":2003,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Heart, Lung, and Blood Institute","keywords":"Conotoxin; Toxin; Gene isoform; Chemistry; Docking (animal); Sodium channel; Biophysics; Mutant; Binding site; Tetrodotoxin; Arginine; Stereochemistry; Crystallography; Biochemistry; Amino acid; Peptide; Biology; Gene; Sodium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004513569,0.000163686,0.0002175171,0.0000588547,0.0004618489,0.0001060304,0.0002171284,0.00008758032,0.000007297479],"category_scores_gemma":[0.0002677458,0.0001185038,0.0002121994,0.0001490977,0.0001657692,0.00001200283,0.0000895827,0.0002559584,0.000005709203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002694293,"about_ca_system_score_gemma":0.00005577042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002984234,"about_ca_topic_score_gemma":0.000002560266,"domain_scores_codex":[0.998953,0.00008093014,0.0003199617,0.0002730881,0.00009341456,0.0002796083],"domain_scores_gemma":[0.9991778,0.0001313208,0.0002057918,0.0002407034,0.0001091899,0.0001352587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004626656,0.0001138785,0.0007098091,0.000005038775,0.0001766276,8.338029e-8,0.00005215982,0.000002295663,0.9942837,0.002786838,0.001079812,0.000743517],"study_design_scores_gemma":[0.009438893,0.0003822334,0.0065051,0.00004603995,0.0002950095,0.000510528,0.001025077,0.00004737419,0.9510183,0.002617697,0.02742835,0.000685416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9441218,0.00006612128,0.05354282,0.001316272,0.0003086093,0.0003747128,0.00008342717,0.000008315209,0.0001779054],"genre_scores_gemma":[0.9967666,0.00004392714,0.001564894,0.0001422984,0.0009524371,0.00006221762,0.00005143453,0.00002589729,0.0003902561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05264482,"threshold_uncertainty_score":0.4832444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02262895337277558,"score_gpt":0.3019217116855271,"score_spread":0.2792927583127515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}