{"id":"W1981661830","doi":"10.1016/s0006-3495(03)74654-2","title":"Novel Interactions Identified between μ-Conotoxin and the Na+ Channel Domain I P-loop: Implications for Toxin-Pore Binding Geometry","year":2003,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Heart, Lung, and Blood Institute","keywords":"Conotoxin; Toxin; Gene isoform; Chemistry; Docking (animal); Sodium channel; Biophysics; Mutant; Binding site; Tetrodotoxin; Arginine; Stereochemistry; Crystallography; Biochemistry; Amino acid; Peptide; Biology; Gene; Sodium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001103812,0.0002850357,0.000301868,0.0001919337,0.0005118194,0.0004138168,0.0004212266,0.0004615381,0.002734032],"category_scores_gemma":[0.0003094383,0.0001372672,0.0002684091,0.0002061141,0.0003308522,0.0005305659,0.0003585602,0.0005795137,0.0004765102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003188864,"about_ca_system_score_gemma":0.000143657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004330517,"about_ca_topic_score_gemma":0.0007087009,"domain_scores_codex":[0.9999028,0.00001371795,0.000005400743,0.00002512836,0.00002585172,0.00002705169],"domain_scores_gemma":[0.9997265,0.00007469417,0.00008879691,0.00002209666,0.00003163634,0.0000564004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000303994,0.00004116615,0.001323499,0.00004144966,0.00001658429,0.0009205114,0.0000590665,0.0003364353,0.9939743,0.0007735702,0.0001019049,0.002107572],"study_design_scores_gemma":[0.00005879474,0.0002645606,0.02520455,0.00001779133,0.00009446837,0.003675821,0.0002853928,0.009357545,0.9569067,0.001228407,0.0028792,0.00002673496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869451,0.0005119297,0.009329221,0.0001213089,0.00003010477,0.0000178084,0.0001133421,0.00005690565,0.00287427],"genre_scores_gemma":[0.9973454,0.0000848242,0.001612931,0.00004694763,0.000006314161,0.000008462693,0.00008112327,0.000006061883,0.0008079876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002734032,"threshold_uncertainty_score":0.009146273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02262895337277558,"score_gpt":0.3019217116855271,"score_spread":0.2792927583127515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}