{"id":"W1981697868","doi":"10.1016/j.ccr.2014.05.029","title":"The Hippo Transducer YAP1 Transforms Activated Satellite Cells and Is a Potent Effector of Embryonal Rhabdomyosarcoma Formation","year":2014,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; National Institutes of Health; Cancer Research UK","keywords":"Embryonal rhabdomyosarcoma; Effector; YAP1; Cell biology; Hippo signaling pathway; Satellite; Biology; Cancer research; Rhabdomyosarcoma; Medicine; Transcription factor; Pathology; Sarcoma; Physics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002020744,0.0001417727,0.0001373978,0.00001455777,0.0001006441,0.00001923635,0.0001175283,0.000114524,0.0000250905],"category_scores_gemma":[0.000003679548,0.00009695853,0.00009379881,0.00004674685,0.00007836038,0.000007132294,0.00001243275,0.00007503514,0.000004058974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001529704,"about_ca_system_score_gemma":0.00004049861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005106607,"about_ca_topic_score_gemma":0.00003548674,"domain_scores_codex":[0.999208,0.00006559299,0.0001980438,0.0002012364,0.0001185333,0.0002086318],"domain_scores_gemma":[0.99957,0.00002885515,0.00007700478,0.0001914235,0.00005839911,0.00007428486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001391419,0.00002291318,0.00004533935,0.0001001008,0.00002528593,1.905273e-7,0.0003953297,0.00002255062,0.9616381,0.000008077724,0.0001107984,0.03749219],"study_design_scores_gemma":[0.0006346859,0.0002214032,0.0001989018,0.00002554516,0.00002592051,0.000001946245,0.00007336984,0.0002184312,0.9451225,0.00003255153,0.05331691,0.0001277816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992411,0.003451566,0.002486481,0.0001718019,0.0001377125,0.0002188998,0.00006519649,0.000009078279,0.001048219],"genre_scores_gemma":[0.9963903,0.002829394,0.00008472065,0.0001792645,0.0001034221,0.00002977599,0.00003839695,0.00001796165,0.0003267553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05320611,"threshold_uncertainty_score":0.3953854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005457978880347183,"score_gpt":0.2114022661222465,"score_spread":0.2059442872418993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}