{"id":"W1981697985","doi":"10.1016/s0166-6851(00)00187-0","title":"Amplification of the ABC transporter gene PGPA and increased trypanothione levels in potassium antimonyl tartrate (SbIII) resistant Leishmania tarentolae","year":2000,"lang":"en","type":"article","venue":"Molecular and Biochemical Parasitology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":131,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Burroughs Wellcome Fund","keywords":"Meglumine antimoniate; Leishmania tropica; Biology; Cutaneous leishmaniasis; Microbiology; Leishmania; Intracellular; Amastigote; Leishmaniasis; Biochemistry; Parasite hosting; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009494812,0.0002331774,0.0002077868,0.0004889262,0.000180201,0.000293273,0.0002283921,0.0004424972,0.003218483],"category_scores_gemma":[0.0004133805,0.000320764,0.0002833145,0.0002213615,0.0003422087,0.0001088054,0.0001717873,0.0004995572,0.000534896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001569755,"about_ca_system_score_gemma":0.00009451307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001085955,"about_ca_topic_score_gemma":0.001010494,"domain_scores_codex":[0.999858,0.0000224964,0.00001558114,0.00003112656,0.00003697792,0.00003574124],"domain_scores_gemma":[0.9997368,0.00008944607,0.00007080107,0.00002906804,0.00003271924,0.00004104312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001832498,0.00003594163,0.0005622578,0.00001540813,0.000005580432,0.0002702948,0.0000376864,0.00001505746,0.9984587,0.0000481059,0.0000164643,0.0003510708],"study_design_scores_gemma":[0.0001497043,0.001167615,0.1307308,0.00001466798,0.0001337626,0.006465706,0.0003371913,0.001443763,0.8574076,0.0001767024,0.00194309,0.00002941896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989485,0.00006836433,0.0005106069,0.00003669217,0.000005966543,0.00001146425,0.0001453661,0.00002356856,0.0002495648],"genre_scores_gemma":[0.9980301,0.00005933383,0.0003339898,0.00002408799,0.000004045422,0.00001279019,0.000327106,0.00001432912,0.001194175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003218483,"threshold_uncertainty_score":0.01076686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01536222723924191,"score_gpt":0.2863379321376905,"score_spread":0.2709757048984486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}