{"id":"W1981713105","doi":"10.1523/jneurosci.2875-05.2006","title":"Calpain-Regulated p35/cdk5 Plays a Central Role in Dopaminergic Neuron Death through Modulation of the Transcription Factor Myocyte Enhancer Factor 2","year":2006,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":180,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Ottawa Hospital; Health Canada","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institutes of Health; Parkinson's Disease Foundation","keywords":"Mef2; Calpain; Dopaminergic; MPTP; Cyclin-dependent kinase 5; Cell biology; Phosphorylation; Transcription factor; Biology; Chemistry; Dopamine; Enhancer; Neuroscience; Protein kinase A; Biochemistry; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001050811,0.0003371962,0.0001425332,0.000171975,0.0002011497,0.0002304219,0.0001603231,0.0001806186,0.0007120832],"category_scores_gemma":[0.00007895058,0.00007695059,0.0001825704,0.00007403005,0.0002167479,0.0002008676,0.000171383,0.0002866406,0.0001257558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003518325,"about_ca_system_score_gemma":0.0001520967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006498354,"about_ca_topic_score_gemma":0.001168241,"domain_scores_codex":[0.9999307,0.000008517382,0.00000638888,0.0000195191,0.00001745022,0.00001733931],"domain_scores_gemma":[0.9999546,0.000004757653,0.00001951847,0.000003460134,0.000004881545,0.0000127611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009035236,0.00001666913,0.0005682175,0.00003037922,0.000004428625,0.000129465,0.00001245116,0.00005945547,0.9975292,0.0001581084,0.00002622242,0.001375058],"study_design_scores_gemma":[0.00002863301,0.0003138843,0.02651367,0.00001074541,0.00002449863,0.0007423356,0.00004344733,0.001274536,0.968271,0.000191714,0.002580656,0.000004849057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910116,0.004636037,0.002888343,0.0001156787,0.00001964739,0.00001547987,0.0001437953,0.00005357988,0.00111591],"genre_scores_gemma":[0.9968609,0.001182643,0.0009260893,0.00002208895,0.000007256685,0.000008194155,0.00009675044,0.000003471921,0.0008926759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007120832,"threshold_uncertainty_score":0.002552748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01280253281961118,"score_gpt":0.2325440682845796,"score_spread":0.2197415354649684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}