{"id":"W1981722629","doi":"10.1089/ten.2006.12.267","title":"Immobilized Concentration Gradients of Neurotrophic Factors Guide Neurite Outgrowth of Primary Neurons in Macroporous Scaffolds","year":2006,"lang":"en","type":"article","venue":"Tissue Engineering","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":221,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Neurite; Neurotrophin; Nerve growth factor; Neurotrophic factors; Dorsal root ganglion; Chemistry; Cell biology; Neurotrophin-3; Growth cone; Spinal cord; Intracellular; Neuroscience; Receptor; Axon; Brain-derived neurotrophic factor; Biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009685082,0.0004892171,0.0003120893,0.0002405798,0.00016539,0.0004599566,0.0002638972,0.0002852426,0.0004073628],"category_scores_gemma":[0.0001339492,0.0002371774,0.0001608645,0.0001572976,0.0002356997,0.0002554439,0.0002319744,0.0003256966,0.0002729365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004620798,"about_ca_system_score_gemma":0.000336913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001662949,"about_ca_topic_score_gemma":0.004980445,"domain_scores_codex":[0.9998572,0.000009776472,0.0000082803,0.00003471714,0.00005010394,0.00004001024],"domain_scores_gemma":[0.9998636,0.00003518349,0.00003240446,0.0000120924,0.00002059046,0.00003606253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001468556,0.000009104231,0.00004483889,0.00001799754,0.000001460925,0.00001714081,0.00001242049,0.0002133997,0.9990224,0.00004650929,0.00001420779,0.0005859589],"study_design_scores_gemma":[0.000008324538,0.00008395482,0.001446209,0.000009587077,0.000008794351,0.00004041576,0.00002852137,0.002901397,0.9943222,0.00004571127,0.00109951,0.000005435727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888405,0.001111112,0.007902323,0.00004989949,0.00004111264,0.00003869977,0.0001367202,0.0001031716,0.001776474],"genre_scores_gemma":[0.9806681,0.001546621,0.0143074,0.00003627416,0.00001904102,0.00006199676,0.000229871,0.00005710886,0.003073629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001662949,"threshold_uncertainty_score":0.003352702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01206504912685994,"score_gpt":0.2283083411622073,"score_spread":0.2162432920353474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}