{"id":"W1981739548","doi":"10.1074/jbc.m202920200","title":"Activation of Go-coupled Dopamine D2 Receptors Inhibits ERK1/ERK2 in Pituitary Cells","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"University of Toronto; Canadian Institutes of Health Research; University of Ottawa","keywords":"Prolactin cell; Dopaminergic; Dopamine; Internal medicine; Dopamine receptor D2; Prolactin; Pertussis toxin; Endocrinology; MAPK/ERK pathway; Protein kinase A; Dopamine receptor; Chemistry; Biology; Cell biology; Kinase; Signal transduction; G protein; Medicine; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008268508,0.0003920816,0.0003094758,0.00016724,0.0001833314,0.0002864663,0.0002126137,0.0001951757,0.001822065],"category_scores_gemma":[0.00007360228,0.0001418224,0.0003674364,0.0001705578,0.0001692274,0.0001604316,0.0002004316,0.0005145339,0.0005701369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000355676,"about_ca_system_score_gemma":0.0002937241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001154559,"about_ca_topic_score_gemma":0.002662401,"domain_scores_codex":[0.9998851,0.00001463431,0.00001110844,0.00002142211,0.00002700589,0.00004073298],"domain_scores_gemma":[0.9999655,0.00000849861,0.000006457342,0.000004754957,0.000004042035,0.00001065605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001238826,0.00003057012,0.00005863016,0.0000418851,0.000004190126,0.00002221116,0.000009265276,0.00003140845,0.9988405,0.00006177985,0.00004196159,0.0007336991],"study_design_scores_gemma":[0.00002738726,0.000246412,0.002743353,0.000004058098,0.00001224437,0.000129303,0.0000291035,0.0005977914,0.9937575,0.00002683991,0.002422857,0.000003266055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939559,0.001446695,0.001826496,0.00013483,0.00003496848,0.00002634376,0.0006416209,0.00006921191,0.001864002],"genre_scores_gemma":[0.9873794,0.001878659,0.00333945,0.00009510813,0.00001346537,0.00006780931,0.002204614,0.00002667896,0.004994819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001822065,"threshold_uncertainty_score":0.00609535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01861263529515185,"score_gpt":0.2317560371266909,"score_spread":0.2131434018315391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}