{"id":"W1981743837","doi":"10.3816/cbc.2007.n.028","title":"Feasibility and Cardiac Safety of Pegylated Liposomal Doxorubicin plus Trastuzumab in Heavily Pretreated Patients with Recurrent HER2-Overexpressing Metastatic Breast Cancer","year":2007,"lang":"en","type":"article","venue":"Clinical Breast Cancer","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"NIH Clinical Center; National Cancer Institute; National Center for Research Resources; Genentech; European Society for Medical Oncology","keywords":"Medicine; Trastuzumab; Ejection fraction; Metastatic breast cancer; Heart failure; Internal medicine; Cardiotoxicity; Breast cancer; Regimen; Oncology; Cancer; Chemotherapy; Surgery; Cardiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004526467,0.0001856508,0.0002521911,0.00008428215,0.0001261376,0.0003042015,0.0001034376,0.0001816099,0.0006368051],"category_scores_gemma":[0.0009087078,0.00009947263,0.0001398738,0.0001035832,0.0002588007,0.0002406665,0.0001311768,0.0003934792,0.000105384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000327723,"about_ca_system_score_gemma":0.0002685983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004393882,"about_ca_topic_score_gemma":0.0005738302,"domain_scores_codex":[0.9998678,0.00006827569,0.00000527777,0.000019052,0.00001730088,0.00002229832],"domain_scores_gemma":[0.9997851,0.00007772919,0.00005921942,0.00002175718,0.00001257015,0.00004364298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1432572,0.003590797,0.1952468,0.0002401746,0.0003585864,0.001272862,0.0006292672,0.004398298,0.465455,0.000836306,0.0008308729,0.1838837],"study_design_scores_gemma":[0.01050642,0.2748333,0.5425568,0.00006064212,0.001040719,0.003728786,0.0006195238,0.02226746,0.138742,0.0006486172,0.00493979,0.00005595839],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993365,0.0001709103,0.0001458827,0.00003753549,0.000003681656,0.00001338563,0.00001050588,0.000003364119,0.0002781441],"genre_scores_gemma":[0.9997802,0.0000433954,0.00007277031,0.00001794926,0.000006293731,0.000006125335,0.00001220104,0.000001292459,0.00005976539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006368051,"threshold_uncertainty_score":0.002393901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03062241698754341,"score_gpt":0.3493528082275875,"score_spread":0.318730391240044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}