{"id":"W1981757238","doi":"10.1016/j.ijpharm.2007.12.029","title":"Enhancement of hydrophilic drug loading and release characteristics through micellization with new carboxymethyldextran-PEG block copolymers of tunable charge density","year":2008,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Surfactants and Colloidal Systems","field":"Chemistry","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Micelle; PEG ratio; Chemistry; Hydrodynamic radius; Copolymer; Ethylene glycol; Polymer chemistry; Poloxamer; Organic chemistry; Aqueous solution; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001810937,0.0002990966,0.0001821157,0.0001366211,0.0001020199,0.0002591343,0.0001273466,0.0002251066,0.000518175],"category_scores_gemma":[0.0001671091,0.0001439194,0.0001619916,0.0001139118,0.0001815018,0.0004410851,0.0001388981,0.0003334673,0.0001781692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002277146,"about_ca_system_score_gemma":0.0001559771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003227908,"about_ca_topic_score_gemma":0.0004165239,"domain_scores_codex":[0.9999275,0.000008417401,0.000007175081,0.00001549072,0.00001917454,0.00002219744],"domain_scores_gemma":[0.9999031,0.00001940159,0.00003502345,0.000008648384,0.00001263099,0.00002119355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004927436,0.00001384178,0.00004098794,0.000008794007,0.000001489862,0.00001777743,0.000007469436,0.0000433399,0.9990348,0.00006729068,0.000006027093,0.0007088886],"study_design_scores_gemma":[0.000008254521,0.00007372438,0.0004296175,6.952313e-7,0.000005490595,0.0000362454,0.000002114757,0.0004768539,0.9986827,0.000008410218,0.0002739496,0.000002038021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961208,0.0005759106,0.002589272,0.00004030629,0.00001188108,0.00001414595,0.00003946823,0.00003866125,0.000569656],"genre_scores_gemma":[0.9967312,0.0004072247,0.001889324,0.00001980591,0.000008863963,0.00001196105,0.0000438474,0.00001627044,0.0008714207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000518175,"threshold_uncertainty_score":0.001733482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02270291601330077,"score_gpt":0.2783735073165714,"score_spread":0.2556705913032706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}