{"id":"W1981758063","doi":"10.1074/jbc.m103872200","title":"Netrin Stimulates Tyrosine Phosphorylation of the UNC-5 Family of Netrin Receptors and Induces Shp2 Binding to the RCM Cytodomain","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Institutes of Health Research; Paralyzed Veterans of America Research Foundation","keywords":"Netrin; Phosphorylation; Tyrosine phosphorylation; Receptor; Cell biology; Tyrosine; Chemistry; Biology; Biochemistry; Axon guidance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004759104,0.0001132393,0.0002301002,0.00002887789,0.00009752388,0.00001634323,0.0003902911,0.0001003637,0.00004586525],"category_scores_gemma":[0.001301826,0.00005513089,0.0001005879,0.000475502,0.0001796432,0.00005766236,0.0001213167,0.0002864014,0.00000102767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002587767,"about_ca_system_score_gemma":0.00003012402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004780769,"about_ca_topic_score_gemma":1.816772e-7,"domain_scores_codex":[0.9988273,0.00008933146,0.0004870688,0.000156333,0.0002807919,0.0001592106],"domain_scores_gemma":[0.9986209,0.0006077242,0.0005159503,0.0001206883,0.00006612662,0.00006866295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001637912,0.00003875782,0.01037489,0.000008056771,0.000004485402,0.000004527607,0.00004167012,0.0003619921,0.9874581,0.00001275211,0.0000937346,0.001437301],"study_design_scores_gemma":[0.0002476937,0.0001856259,0.01643504,0.00007998401,0.000008931124,0.00004540921,0.0001098726,0.00003788441,0.9818529,0.0001358719,0.0007952233,0.00006554336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998631,0.0004663386,0.00004774653,0.0004750914,0.0001103159,0.00007839538,0.000005621046,0.000004693272,0.0001808216],"genre_scores_gemma":[0.9991289,0.0003826752,0.00007648743,0.0002361591,0.0001163973,8.156756e-7,2.987772e-7,0.000005043354,0.00005317457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006060145,"threshold_uncertainty_score":0.2248172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06076536604900602,"score_gpt":0.2761979018353421,"score_spread":0.2154325357863361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}