{"id":"W1981786006","doi":"10.3390/molecules20023255","title":"Design, Synthesis, and Cytotoxicity of Perbutyrylated Glycosides of 4β-Triazolopodophyllotoxin Derivatives","year":2015,"lang":"en","type":"article","venue":"Molecules","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"Institute of Botany, Chinese Academy of Sciences; Kunming Institute of Botany, Chinese Academy of Sciences; State Key Laboratory of Phytochemistry and Plant Resources in West China; Chinese Academy of Sciences","keywords":"Podophyllotoxin; Chemistry; Cytotoxicity; Cycloaddition; Stereochemistry; MTT assay; Residue (chemistry); Triazole; Etoposide; Click chemistry; Glycoside; Combinatorial chemistry; In vitro; Organic chemistry; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003451678,0.0001816784,0.0003216723,0.00005965961,0.00003266029,0.00001014022,0.0001636753,0.0001573058,0.000004871803],"category_scores_gemma":[0.0004160987,0.0001535462,0.00006919574,0.00008821999,0.0002578625,0.000006555169,0.0001093052,0.00005005186,9.133672e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007670523,"about_ca_system_score_gemma":0.00008885824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000035669,"about_ca_topic_score_gemma":0.000008564061,"domain_scores_codex":[0.9988827,0.0002240916,0.0002655721,0.0002832175,0.0001550242,0.0001894114],"domain_scores_gemma":[0.9992523,0.00009451724,0.0001930499,0.0002437933,0.0001213906,0.00009493135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002773675,0.0001192025,0.002377207,0.00003703651,0.00009350601,0.000002624618,0.00007718237,0.00004420074,0.9960896,0.00003671601,0.0001060395,0.000739345],"study_design_scores_gemma":[0.0002907267,0.0003323825,0.005374542,0.00004245163,0.00003033386,0.000008823517,0.000138508,0.0001426961,0.9932836,0.00009145369,0.00009430517,0.0001701458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914026,0.0009089406,0.00710378,0.00005331792,0.00002269841,0.0001901992,0.00006269185,0.00001037497,0.000245391],"genre_scores_gemma":[0.9932431,0.0001571553,0.006483834,0.00002872566,0.00002329116,0.00001656655,0.00001226364,0.00001725822,0.00001782805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002997335,"threshold_uncertainty_score":0.6261433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02930071843879845,"score_gpt":0.2404764968221274,"score_spread":0.211175778383329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}