{"id":"W1981786006","doi":"10.3390/molecules20023255","title":"Design, Synthesis, and Cytotoxicity of Perbutyrylated Glycosides of 4β-Triazolopodophyllotoxin Derivatives","year":2015,"lang":"en","type":"article","venue":"Molecules","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"Institute of Botany, Chinese Academy of Sciences; Kunming Institute of Botany, Chinese Academy of Sciences; State Key Laboratory of Phytochemistry and Plant Resources in West China; Chinese Academy of Sciences","keywords":"Podophyllotoxin; Chemistry; Cytotoxicity; Cycloaddition; Stereochemistry; MTT assay; Residue (chemistry); Triazole; Etoposide; Click chemistry; Glycoside; Combinatorial chemistry; In vitro; Organic chemistry; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009155195,0.000339584,0.0002255486,0.0002255163,0.00009109475,0.0002371439,0.000197913,0.0001632659,0.0005415107],"category_scores_gemma":[0.0000827938,0.0001163922,0.0002123849,0.0002865272,0.0001228447,0.0002154817,0.0001311922,0.0003286078,0.000226521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002381574,"about_ca_system_score_gemma":0.0001494469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002569582,"about_ca_topic_score_gemma":0.0004585924,"domain_scores_codex":[0.9999502,0.000007585951,0.000007648126,0.00000994026,0.00001227313,0.00001241598],"domain_scores_gemma":[0.9999235,0.00000498947,0.000033027,0.000008997713,0.00001304798,0.00001653035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006477213,0.00003826176,0.0001164295,0.00004761912,0.000006678117,0.00006633117,0.00001215253,0.0004219382,0.9959599,0.0001255123,0.00002117938,0.003119231],"study_design_scores_gemma":[0.000036078,0.001026803,0.001596695,0.000006142207,0.00003449068,0.0002338866,0.00001589843,0.0007342344,0.99357,0.00004824595,0.002690241,0.000007288739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900241,0.002067855,0.005483227,0.00007901037,0.00002351843,0.00009909742,0.0002927712,0.00005260876,0.001877761],"genre_scores_gemma":[0.9895718,0.002359516,0.005604357,0.0000453502,0.00001036395,0.00006365369,0.0005012429,0.00001181178,0.001831868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005415107,"threshold_uncertainty_score":0.001811504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02930071843879845,"score_gpt":0.2404764968221274,"score_spread":0.211175778383329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}