{"id":"W1981811485","doi":"10.1016/j.bpj.2008.12.2462","title":"Molecular Action Of CFTR Potentiators On The Kca3.1 Channel","year":2009,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Potentiator; ΔF508; Cystic fibrosis transmembrane conductance regulator; Cystic fibrosis; Xenopus; Chloride channel; Chemistry; Gating; Cell biology; Patch clamp; Mutation; Secretion; Biology; Biochemistry; Biophysics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005481205,0.0003364884,0.0005248177,0.0002240694,0.0004292962,0.0006582148,0.0005042196,0.000853907,0.004066363],"category_scores_gemma":[0.001106659,0.0003079086,0.0004354089,0.0001548088,0.0006489024,0.0006204614,0.0005493372,0.001257044,0.0009407485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004595943,"about_ca_system_score_gemma":0.0004183979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004978136,"about_ca_topic_score_gemma":0.000468994,"domain_scores_codex":[0.9996825,0.00008255111,0.0000251992,0.00002884021,0.00008039294,0.0001004612],"domain_scores_gemma":[0.9995593,0.0002566156,0.00004919624,0.00004092706,0.00003849515,0.00005536465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002705858,0.00006010525,0.0002403634,0.0002627659,0.00002933207,0.0004651233,0.000103447,0.0002593855,0.9891978,0.001605216,0.0004552666,0.004615412],"study_design_scores_gemma":[0.000716017,0.001259413,0.003515425,0.00007487141,0.0001146877,0.001325854,0.0001208049,0.002035137,0.9845963,0.0007410439,0.005465575,0.00003488564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814854,0.008460777,0.001409945,0.001783216,0.0003762308,0.00005345329,0.0003503282,0.0001277004,0.005952995],"genre_scores_gemma":[0.9930648,0.004595957,0.0007465393,0.0003568833,0.000156524,0.00003162278,0.0001350561,0.00002686277,0.0008857806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004066363,"threshold_uncertainty_score":0.01360327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02229929719584102,"score_gpt":0.3188510844044111,"score_spread":0.2965517872085701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}