{"id":"W1981812861","doi":"10.1128/aac.49.5.1943-1948.2005","title":"Pharmacodynamic Activity of Telithromycin at Simulated Clinically Achievable Free-Drug Concentrations in Serum and Epithelial Lining Fluid against Efflux ( <i>mefE</i> )-Producing Macrolide- Resistant <i>Streptococcus pneumoniae</i> for Which Telithromycin MICs Vary","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Health Sciences Centre","funders":"","keywords":"Telithromycin; Streptococcus pneumoniae; Pharmacokinetics; Microbiology; Pharmacodynamics; Ketolide; Antibacterial agent; Efflux; Pharmacology; Chemistry; Antibiotics; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003209539,0.0002985468,0.0004319517,0.00008319585,0.00007033115,0.0005781273,0.0002682876,0.0003673485,0.0004149883],"category_scores_gemma":[0.001015557,0.0001406474,0.000290326,0.00008671967,0.0001948665,0.0002881511,0.0001600556,0.0003401701,0.0001568061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005468725,"about_ca_system_score_gemma":0.0004675649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001287587,"about_ca_topic_score_gemma":0.0008737069,"domain_scores_codex":[0.9996079,0.0001744285,0.00002160004,0.00005400487,0.0001027343,0.00003942077],"domain_scores_gemma":[0.9995485,0.000222063,0.000103125,0.00002625396,0.000062884,0.00003720765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004019198,0.0001548618,0.00600255,0.0002549416,0.00009835215,0.0001624179,0.00009260466,0.01338156,0.9651603,0.0001319451,0.0002186041,0.01032247],"study_design_scores_gemma":[0.0001731172,0.008305176,0.01242922,0.00002149775,0.000151968,0.0007221882,0.0001726023,0.04714546,0.9287769,0.0001544989,0.001904855,0.0000423366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945915,0.001114411,0.003449619,0.00006940513,0.0000107131,0.00002558735,0.0002672383,0.00005692805,0.0004145601],"genre_scores_gemma":[0.997969,0.0003800237,0.001211526,0.00004643341,0.000004626211,0.00001495685,0.0002019008,0.000007018678,0.0001645082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001287587,"threshold_uncertainty_score":0.003967881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01250258994645172,"score_gpt":0.289382507772369,"score_spread":0.2768799178259173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}