{"id":"W1981844581","doi":"10.1016/j.dnarep.2010.10.001","title":"Mre11–Rad50–Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks","year":2010,"lang":"en","type":"review","venue":"DNA repair","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":223,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; National Institutes of Health","keywords":"Rad50; Effector; Biology; DNA repair; Homologous recombination; DNA; DNA damage; Computational biology; Telomere; Cell biology; Genetics; Nijmegen breakage syndrome; DNA-binding protein; Ataxia-telangiectasia; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001134412,0.0004865683,0.001237134,0.00009769481,0.0001955993,0.00004888133,0.0002082496,0.0006913158,0.00001857776],"category_scores_gemma":[0.0002483873,0.0003254139,0.0005803614,0.00008461928,0.0005823552,0.000006921565,0.0002019757,0.0003173055,0.00000806849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001845978,"about_ca_system_score_gemma":0.0001805604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002734153,"about_ca_topic_score_gemma":0.00004573946,"domain_scores_codex":[0.9977834,0.0004548204,0.0007117998,0.0005245943,0.0002161862,0.0003092249],"domain_scores_gemma":[0.9979586,0.0003969768,0.0005700681,0.0008092036,0.0001228472,0.0001422958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007326203,0.0002743864,0.00010917,0.03256595,0.005852163,0.0001034589,0.001061024,0.000003720666,0.3072575,0.003012784,0.007696474,0.6347371],"study_design_scores_gemma":[0.003761499,0.0002750264,0.000005203864,0.0009268799,0.001047898,0.0005485823,0.00001702907,0.00005482118,0.01548031,0.00001978564,0.9774604,0.000402606],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04121074,0.9553632,0.0001548962,0.00005120466,0.0002771754,0.001982018,0.0003750763,0.00007466857,0.0005110668],"genre_scores_gemma":[0.02003077,0.976966,0.0004042155,0.0001587854,0.0002619129,0.000106295,0.0003937547,0.00009817199,0.001580065],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9697639,"threshold_uncertainty_score":0.9999198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01316843230959538,"score_gpt":0.2713386896779882,"score_spread":0.2581702573683929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}