{"id":"W1981861436","doi":"10.1186/bcr2316","title":"A randomized, phase III trial exploring the effects of neoadjuvant sequential treatment with steroidal (exemestane) and nonsteroidal (anastrozole) aromatase inhibitors on biomarkers in postmenopausal women with hormone receptor-positive locally advanced breast cancer","year":2009,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Sunnybrook Hospital; Women's College Hospital; Princess Margaret Cancer Centre","funders":"AstraZeneca","keywords":"Anastrozole; Exemestane; Medicine; Aromatase; Oncology; Breast cancer; Aromatase inhibitor; Internal medicine; Surgical oncology; Nonsteroidal; Randomized controlled trial; Hormone receptor; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006215607,0.0004178848,0.000621871,0.0002099251,0.0001829157,0.00006065439,0.0001975664,0.0001375801,0.000007274769],"category_scores_gemma":[0.00001442427,0.0002425686,0.00007292413,0.0003865468,0.0006432339,0.00003534909,0.00007611458,0.0003578319,9.885658e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003303713,"about_ca_system_score_gemma":0.0005241343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001185581,"about_ca_topic_score_gemma":0.0001148141,"domain_scores_codex":[0.9968541,0.0007058612,0.0003814084,0.0006734239,0.0005869503,0.0007982075],"domain_scores_gemma":[0.9988729,0.000149107,0.0001654174,0.0003625422,0.0001676035,0.0002824827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6045334,0.000586291,0.00004050623,0.00002532056,0.0005820789,0.0001043669,0.0004620959,0.00007530923,0.3209842,0.000004423327,0.00003058093,0.07257141],"study_design_scores_gemma":[0.7832748,0.03532454,0.001325062,0.0008649956,0.0001379336,0.0002561937,0.0006492133,0.00005669761,0.1776267,0.000004104633,0.00004584666,0.0004340114],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929113,0.002724336,0.00002265206,0.0005376572,0.0001061011,0.003350015,0.0003001664,0.00001304359,0.00003474858],"genre_scores_gemma":[0.9947957,0.002961511,0.00003558716,0.00004655348,0.0002287032,0.001779001,0.00007630455,0.00004352284,0.00003308255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1787414,"threshold_uncertainty_score":0.989166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147192916365039,"score_gpt":0.2966248066512854,"score_spread":0.285152877487635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}