{"id":"W1981861436","doi":"10.1186/bcr2316","title":"A randomized, phase III trial exploring the effects of neoadjuvant sequential treatment with steroidal (exemestane) and nonsteroidal (anastrozole) aromatase inhibitors on biomarkers in postmenopausal women with hormone receptor-positive locally advanced breast cancer","year":2009,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Sunnybrook Hospital; Women's College Hospital; Princess Margaret Cancer Centre","funders":"AstraZeneca","keywords":"Anastrozole; Exemestane; Medicine; Aromatase; Oncology; Breast cancer; Aromatase inhibitor; Internal medicine; Surgical oncology; Nonsteroidal; Randomized controlled trial; Hormone receptor; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002868,0.001488554,0.002740488,0.000459367,0.0005741669,0.00091023,0.000849531,0.00186871,0.005858756],"category_scores_gemma":[0.004745699,0.0005887036,0.001826451,0.0004930863,0.001628199,0.001181943,0.000549375,0.003031463,0.0007952463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008388638,"about_ca_system_score_gemma":0.002208234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001053224,"about_ca_topic_score_gemma":0.002311658,"domain_scores_codex":[0.9988121,0.0007992328,0.00006954501,0.0001441407,0.00006064725,0.0001143973],"domain_scores_gemma":[0.9966704,0.00150652,0.0004917904,0.0002980395,0.0001482301,0.0008850191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9845902,0.007129024,0.0003053221,0.0001838841,0.0003635447,0.00002316356,0.00002852218,0.0002192287,0.001515244,0.00007655091,0.0002809133,0.005284371],"study_design_scores_gemma":[0.9205971,0.07786885,0.0004939311,0.00001110609,0.0002352305,0.00001657527,0.00001469241,0.000183454,0.0002057493,0.0001252512,0.0002402239,0.000007823856],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830216,0.002975652,0.0008985213,0.001446658,0.001093384,0.007304029,0.001100714,0.00007895606,0.002080639],"genre_scores_gemma":[0.9763825,0.002445689,0.003445313,0.001609089,0.0007535129,0.01050565,0.00128229,0.00003042321,0.003545527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005858756,"threshold_uncertainty_score":0.0195995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147192916365039,"score_gpt":0.2966248066512854,"score_spread":0.285152877487635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}